SynthesisNature communications2018
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 167 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
167citing papers in PubMed, 4 pooled it
12.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
167 citing papers in PubMed, 4 syntheses or guidelines pooled it, 273 citations in OpenAlex.
- Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights.European urology · 2023Pooled it
- Role of Polygenic Risk Score in Cancer Precision Medicine of Non-European Populations: A Systematic Review.Current oncology (Toronto, Ont.) · 2022Pooled it
- Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer.Nature communications · 2020Pooled it
- Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer.Journal of the National Cancer Institute · 2019Pooled it
- Results of a multigene panel testing approach targeting patients with suspected genetic predisposition to pancreatic ductal adenocarcinoma.European journal of human genetics : EJHG · 2026Article
- Nonlinear Modeling Reveals Novel Associations Between Genetically Predicted Protein Levels and Pancreatic Cancer Risk.Molecular carcinogenesis · 2026Article
- Exploring imputation performance of phenotype-associated SNPs for forensic prediction models.Scientific reports · 2026Article
- Polygenic scores for risk of pancreatic ductal adenocarcinoma: evaluation of novel and published models.NPJ precision oncology · 2026Article
- Pancreatic cancer.Nature reviews. Disease primers · 2026Review
- Low genetic risk for coronary artery disease underlies multigenerational longevity and healthy aging.GeroScience · 2026Article
- Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Novel Genetic Risk Loci for Pancreatic Ductal Adenocarcinoma Identified in a Genome-wide Study of African Ancestry Individuals.medRxiv : the preprint server for health sciences · 2026Article
- Characterization of a pancreatic cancer GWAS signal suggests PDX1 buffers stress in the exocrine pancreas.medRxiv : the preprint server for health sciences · 2026Article
- Identifying Plasma Proteins Associated with Risk of Solid Cancers: A 25-Year Prospective Analysis of 4,712 Circulating Proteins in the ARIC Study.medRxiv : the preprint server for health sciences · 2026Article
- Detection of mutated KRAS, TP53, CDKN2A, and SMAD4 in tumor cell-free DNA of Brazilian pancreatic adenocarcinoma patients using next-generation sequencing.Scientific reports · 2026Article
- Integrative screening identifies functional variants and VNTRs underlying GWAS signals at the 5p15.33 multi-cancer susceptibility locus.medRxiv : the preprint server for health sciences · 2026Article
- Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis.Journal of the National Cancer Institute · 2026Article
- DNA methylation-mediated silencing of HNF1B promotes bladder cancer progression.Clinical epigenetics · 2026Article
- Beyond sensitivity and specificity: Redefining the era connotation of "low-risk" in pancreatic cancer screening.World journal of clinical oncology · 2026Article
- Predictive prioritization of enhancers associated with pancreatic disease risk.Cell genomics · 2026Article
107 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
123 authors at 20 institutions in 17 countries.
Alison P KleinDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, 21231, USA. aklein1@jhmi.edu.
Brian M WolpinDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Harvey A RischDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, 06520, USA.
Rachael Z Stolzenberg-SolomonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Evelina MocciDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, 21231, USA.ORCID http://orcid.org/0000-0002-7101-9556
Mingfeng ZhangLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-4261-4583
Erica J ChildsDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, 21231, USA.
Jason W HoskinsLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Ashley JermusykLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Jun ZhongLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Fei ChenDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, 21231, USA.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Gabriella AndreottiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Alan A ArslanDepartment of Obstetrics and Gynecology, New York University School of Medicine, New York, NY, 10016, USA.
Ana BabicDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
William R BamletDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA.
Laura Beane-FreemanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Amanda BlackfordDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, 21231, USA.
Michael BorgesDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.
Ayelet BorgidaLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, M5G 1×5, Canada.
Paige M BracciDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 94158, USA.
Lauren BraisDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Paul BrennanInternational Agency for Research on Cancer (IARC), 69372, Lyon, France.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Bas Bueno-de-MesquitaDepartment for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), 3720 BA, Bilthoven, The Netherlands.
Julie BuringDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Daniele CampaDepartment of Biology, University of Pisa, 56126, Pisa, Italy.
Gabriele CapursoDigestive and Liver Disease Unit, 'Sapienza' University of Rome, 00185, Rome, Italy.
Giulia Martina CavestroGastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
Kari G ChaffeeDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA.ORCID http://orcid.org/0000-0002-7313-1875
Charles C ChungDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Sean ClearyLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, M5G 1×5, Canada.
Michelle CotterchioCancer Care Ontario, University of Toronto, Toronto, Ontario, M5G 2L7, Canada.
Frederike DijkDepartment of Pathology, Academic Medical Center, University of Amsterdam, 1007 MB, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-3970-6601
Eric J DuellUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute (IDIBELL), Catalan Institute of Oncology (ICO), Barcelona, 08908, Spain.
Lenka ForetovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, 65653, Brno, Czech Republic.
Charles FuchsYale Cancer Center, New Haven, CT, 06510, USA.
Niccola FunelDepartment of Translational Research and The New Technologies in Medicine and Surgery, University of Pisa, 56126, Pisa, Italy.
Steven GallingerLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, M5G 1×5, Canada.
J Michael M GazianoDivision of Aging, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Maria GazouliDepartment of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, 106 79, Athens, Greece.ORCID http://orcid.org/0000-0002-3295-6811
Graham G GilesCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, 3004, Australia.
Edward GiovannucciDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Michael GogginsDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.
Gary E GoodmanDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Phyllis J GoodmanSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Thilo HackertDepartment of General Surgery, University Hospital Heidelberg, 69120, Heidelberg, Germany.
Christopher HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90032, USA.
Patricia HartgeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Manal HasanDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, 77230, USA.
Peter HegyiFirst Department of Medicine, University of Szeged, 6725, Szeged, Hungary.
Kathy J HelzlsouerDivision of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Joseph HermanDepartment of Radiation Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, 21231, USA.
Ivana HolcatovaInstitute of Public Health and Preventive Medicine, Charles University, 2nd Faculty of Medicine, 150 06, Prague 5, Czech Republic.
Elizabeth A HollyDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 94158, USA.
Robert HooverDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Rayjean J HungLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, M5G 1×5, Canada.
Eric J JacobsEpidemiology Research Program, American Cancer Society, Atlanta, GA, 30303, USA.ORCID http://orcid.org/0000-0002-8458-7659
Krzysztof JamroziakDepartment of Hematology, Institute of Hematology and Transfusion Medicine, 02-776, Warsaw, Poland.
Vladimir JanoutDepartment of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava, 701 03, Ostrava, Czech Republic.
Rudolf KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Kay-Tee KhawSchool of Clinical Medicine, University of Cambridge, Cambridge, CB2 0SP, UK.
Eric A KleinGlickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.ORCID http://orcid.org/0000-0002-1783-0698
Manolis KogevinasISGlobal, Centre for Research in Environmental Epidemiology (CREAL), 08003, Barcelona, Spain.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Matthew H KulkeDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Juozas KupcinskasDepartment of Gastroenterology, Lithuanian University of Health Sciences, 44307, Kaunas, Lithuania.
Robert J KurtzDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Daniel LaheruDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, 21231, USA.
Stefano LandiDepartment of Biology, University of Pisa, 56126, Pisa, Italy.
Rita T LawlorARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona, 37134, Verona, Italy.
I-Min LeeDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Loic LeMarchandCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, 96813, USA.
Lingeng LuDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, 06520, USA.ORCID http://orcid.org/0000-0001-9871-0809
Núria MalatsGenetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), 28029, Madrid, Spain.ORCID http://orcid.org/0000-0003-2538-3784
Andrea MambriniOncology Department, ASL1 Massa Carrara, Carrara, 54033, Italy.
Satu MannistoDepartment of Public Health Solutions, National Institute for Health and Welfare, 00271, Helsinki, Finland.
Roger L MilneCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, 3004, Australia.ORCID http://orcid.org/0000-0001-5764-7268
Beatrice Mohelníková-DuchoňováDepartment of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital, 775 20, Olomouc, Czech Republic.
Rachel E NealePopulation Health Department, QIMR Berghofer Medical Research Institute, Brisbane, 4029, Australia.
John P NeoptolemosDepartment of General Surgery, University of Heidelburg, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-6201-7399
Ann L ObergDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA.ORCID http://orcid.org/0000-0003-2539-9807
Sara H OlsonDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Irene OrlowDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Claudio PasqualiDepartment of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, 35124, Padua, Italy.
Alpa V PatelEpidemiology Research Program, American Cancer Society, Atlanta, GA, 30303, USA.
Ulrike PetersDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Raffaele PezzilliPancreas Unit, Department of Digestive Diseases and Internal Medicine, Sant'Orsola-Malpighi Hospital, 40138, Bologna, Italy.ORCID http://orcid.org/0000-0001-9827-7451
Miquel PortaCIBER Epidemiología y Salud Pública (CIBERESP), 08003, Barcelona, Spain.ORCID http://orcid.org/0000-0003-1684-7428
Francisco X RealCIBERONC, 28029, Madrid, Spain.ORCID http://orcid.org/0000-0001-9501-498X
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Ghislaine SceloInternational Agency for Research on Cancer (IARC), 69372, Lyon, France.
Howard D SessoDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Gianluca SeveriCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, 3004, Australia.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.
Debra SilvermanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Jill P SmithDepartment of Medicine, Georgetown University, Washington, 20057, USA.
Pavel SoucekLaboratory for Pharmacogenomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, 323 00, Pilsen, Czech Republic.
Malin SundDepartment of Surgical and Perioperative Sciences, Umeå University, 901 85, Umeå, Sweden.ORCID http://orcid.org/0000-0002-7516-9543
Renata Talar-WojnarowskaDepartment of Digestive Tract Diseases, Medical University of Łodz, 90-647, Łodz, Poland.
Francesca TavanoDivision of Gastroenterology and Research Laboratory, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", 71013, San Giovanni Rotondo, FG, Italy.
Mark D ThornquistDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Geoffrey S TobiasDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0002-2878-8253
Stephen K Van Den EedenDivision of Research, Kaiser Permanente Northern California, Oakland, CA, 94612, USA.ORCID http://orcid.org/0000-0002-5599-8387
Yogesh VashistDepartment of General, Visceral and Thoracic Surgery, University Hamburg-Eppendorf, 20246, Hamburg, Germany.
Kala VisvanathanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Pavel VodickaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 142 20, Prague 4, Czech Republic.
Jean Wactawski-WendeDepartment of Epidemiology and Environmental Health, University at Buffalo, Buffalo, NY, 14214, USA.
Zhaoming WangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Emily WhiteDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Herbert YuCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, 96813, USA.ORCID http://orcid.org/0000-0003-3950-4815
Kai YuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Anne Zeleniuch-JacquotteDepartment of Population Health, New York University School of Medicine, New York, NY, 10016, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.ORCID http://orcid.org/0000-0003-1226-070X
Peter KraftDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Donghui LiDepartment of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Stephen ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Ofure ObazeeGenomic Epidemiology Group, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-8791-5008
Gloria M PetersenDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA.
Laufey T AmundadottirLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA. amundadottirl@mail.nih.gov.ORCID http://orcid.org/0000-0003-1859-8971
National Institutes of Health · USJohns Hopkins University · USDana-Farber Cancer Institute · USFred Hutch Cancer Center · USBrigham and Women's Hospital · USGerman Cancer Research Center · DEMayo Clinic · USMount Sinai Hospital · CAMemorial Sloan Kettering Cancer Center · USUniversity of Pisa · ITAmerican Cancer Society · USCentre international de recherche sur le cancer · FRCharles University · CZHeidelberg University · DENew York University · USThe University of Melbourne · AUThe University of Texas MD Anderson Cancer Center · USUniversitat Autònoma de Barcelona · ESUniversity of California, San Francisco · USUniversity of Hawaiʻi at Mānoa · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MSWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MLaboratory of Translational GenomicsZIACP010201 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI PROKUNINA-OLSSON, LIUDMILA · 2010 to 2025
$91.2MVaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1MSWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8MTumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI THOMPSON, ELIZABETH D · 1993 to 2022
$54.6MTissue CoreP50CA102701 · NCI · MAYO CLINIC ROCHESTER · PI MUKHOPADHYAY, DEBABRATA · 2004 to 2018
$32.7MWomen's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2MRESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ZELIKOFF, JUDITH TERRY · 1985 to 2020
$26.1MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MCancer Research UK 14136CCR NIH HHS HHSN261200800001CMedical Research Council G0401527Medical Research Council G1000143Medical Research Council MR/N003284/1NCATS NIH HHS UL1 TR001863NCCDPHP CDC HHS U58 DP003862NCI NIH HHS HHSN261200800001ENCI NIH HHS P01 CA087969NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016087NCI NIH HHS P50 CA062924NCI NIH HHS P50 CA102701NCI NIH HHS R01 CA034944NCI NIH HHS R01 CA040360NCI NIH HHS R01 CA047988NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA097075NCI NIH HHS R01 CA097193NCI NIH HHS R01 CA098661NCI NIH HHS R01 CA098870NCI NIH HHS R01 CA102765NCI NIH HHS R01 CA109767NCI NIH HHS R01 CA154823NCI NIH HHS R03 CA123546NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA167462NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA210171NCI NIH HHS U10 CA037429NCI NIH HHS U24 CA074783NCI NIH HHS UG1 CA189974NCI NIH HHS UM1 CA167462NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA182883NCI NIH HHS UM1 CA182934NCI NIH HHS UM1 CA186107NHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS R01 HL026490NHLBI NIH HHS R01 HL034595NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL080467NHLBI NIH HHS RC1 HL099355NIEHS NIH HHS P30 ES000260World Health Organization 001
Abstract
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10
Indexed as
Carcinoma, Pancreatic DuctalDatabases, GeneticGenetic Predisposition to DiseaseGenome-Wide Association StudyHepatocyte Nuclear Factor 1-betaHepatocyte Nuclear Factor 4HumansIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsPancreatic NeoplasmsPolymorphism, Single NucleotideProteinsRepressor ProteinsTensinsHepatocyte Nuclear Factor 1-betaHepatocyte Nuclear Factor 4HNF1B protein, humanHNF4G protein, humanIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsNOC2L protein, humanProteinsRepressor ProteinsTensinsTNS3 protein, humanUcma protein, human
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