ArticleScientific reports2018
Depiction of pneumothoraces in a large animal model using x-ray dark-field radiography.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 42 citations in OpenAlex.
- Realistic wave-optics simulation of X-ray dark-field imaging at a human scale.Scientific reports · 2025Article
- Dark-field chest radiography signal characteristics in inspiration and expiration in healthy and emphysematous subjects.European radiology experimental · 2025Article
- Grating-based x-ray dark-field CT for lung cancer diagnosis in mice.European radiology experimental · 2024Article
- A Semi-quantitative Scoring System for Green Histopathological Evaluation of Large Animal Models of Acute Lung Injury.Bio-protocol · 2022Article
- Dark-field chest x-ray imaging: first experience in patients with alpha1-antitrypsin deficiency.European radiology experimental · 2022Article
- X-ray dark-field chest imaging for detection and quantification of emphysema in patients with chronic obstructive pulmonary disease: a diagnostic accuracy study.The Lancet. Digital health · 2021Article
- Signal Retrieval from Non-Sinusoidal Intensity Modulations in X-ray and Neutron Interferometry Using Piecewise-Defined Polynomial Function.Journal of imaging · 2021Article
- X-ray dark-field radiography for in situ gout diagnosis by means of an ex vivo animal study.Scientific reports · 2021Article
- Quantitative analysis of speckle-based X-ray dark-field imaging using numerical wave-optics simulations.Scientific reports · 2021Article
- Correlation of image quality parameters with tube voltage in X-ray dark-field chest radiography: a phantom study.Scientific reports · 2021Article
- Whole-body x-ray dark-field radiography of a human cadaver.European radiology experimental · 2021Article
- A proof-of principal study using phase-contrast imaging for the detection of large airway pathologies after lung transplantation.Scientific reports · 2020Article
- Imaging characteristics of intravascular spherical contrast agents for grating-based x-ray dark-field imaging - effects of concentrations, spherical sizes and applied voltage.Scientific reports · 2020Article
- Imaging features in post-mortem x-ray dark-field chest radiographs and correlation with conventional x-ray and CT.European radiology experimental · 2019Article
- A 3-D Projection Model for X-ray Dark-field Imaging.Scientific reports · 2019Article
- Optimization of tube voltage in X-ray dark-field chest radiography.Scientific reports · 2019Article
- Article
- Translation from murine to human lung imaging using x-ray dark field radiography: A simulation study.PloS one · 2018Article
Corrections and comments
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Authors and funding
25 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to assess the diagnostic value of x-ray dark-field radiography to detect pneumothoraces in a pig model. Eight pigs were imaged with an experimental grating-based large-animal dark-field scanner before and after induction of a unilateral pneumothorax. Image contrast-to-noise ratios between lung tissue and the air-filled pleural cavity were quantified for transmission and dark-field radiograms. The projected area in the object plane of the inflated lung was measured in dark-field images to quantify the collapse of lung parenchyma due to a pneumothorax. Means and standard deviations for lung sizes and signal intensities from dark-field and transmission images were tested for statistical significance using Student's two-tailed t-test for paired samples. The contrast-to-noise ratio between the air-filled pleural space of lateral pneumothoraces and lung tissue was significantly higher in the dark-field (3.65 ± 0.9) than in the transmission images (1.13 ± 1.1; p = 0.002). In case of dorsally located pneumothoraces, a significant decrease (-20.5%; p > 0.0001) in the projected area of inflated lung parenchyma was found after a pneumothorax was induced. Therefore, the detection of pneumothoraces in x-ray dark-field radiography was facilitated compared to transmission imaging in a large animal model.
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