Evidence map›Paper›PMID 29422442›Full record

Trial reportBrain stimulation

Pallidal deep brain stimulation modulates excessive cortical high β phase amplitude coupling in Parkinson disease.

Mahsa Malekmohammadi, Nicholas AuYong, Joni Ricks-Oddie, Yvette Bordelon, Nader Pouratian

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 70 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mahsa MalekmohammadiDepartment of Neurosurgery, University of California, Los Angeles, CA, USA. Electronic address: mmalekmohammadi@mednet.ucla.edu.
Nicholas AuYongDepartment of Neurosurgery, University of California, Los Angeles, CA, USA.
Joni Ricks-OddieInstitute for Digital Research and Education (IDRE), University of California, Los Angeles, CA, USA.
Yvette BordelonDepartment of Neurology, University of California, Los Angeles, CA, USA.
Nader PouratianDepartment of Neurosurgery, University of California, Los Angeles, CA, USA; Department of Bioengineering, University of California, Los Angeles, CA, USA; Neuroscience Interdepartmental Program, University of California, Los Angeles, CA, USA; Brain Research Institute, University of California, Los Angeles, CA, USA.
University of California, Los Angeles · US

Funding

The Pathophysiology of Network Synchrony in Parkinson's DiseaseR01NS097782 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI NADER POURATIAN · 2016 to 2026
$5.2M
UCLA Neurosurgery Research Training and Education ProgramR25NS079198 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIAU, LINDA M · 2012 to 2021
$1.2M
Electrophysiologic and Anatomic Basis of BOLD fMRIK23EB014326 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI POURATIAN, NADER · 2012 to 2016
$946k
NIBIB NIH HHS K23 EB014326NINDS NIH HHS R01 NS097782NINDS NIH HHS R25 NS079198
6 · The paper itself

Abstract

objectiveDeep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) are equally efficacious in the management of Parkinson disease (PD). Studies of STN-DBS have revealed a therapeutic reduction in excessive cortical β-γ phase-amplitude coupling (PAC). It is unclear whether this is specific to STN-DBS and potentially mediated by modulation of the hyperdirect pathway or if it is a generalizable mechanism seen with DBS of other targets. Moreover, it remains unclear how cortical signals are differentially modulated by movement versus therapy. To clarify, the effects of GPi-DBS and movement on cortical β power and β-γ PAC were examined.

methodsRight sensorimotor electrocorticographic signals were recorded in 10 PD patients undergoing GPi-DBS implantation surgery. We evaluated cortical β power and β-γ PAC during blocks of rest and contralateral hand movement (finger tapping) with GPi-DBS off and on.

resultsMovement suppressed cortical low β power (P = 0.008) and high β-γ PAC (P = 0.028). Linear mixed effect modeling (LMEM) showed that power in low and high β bands are differentially modulated by movement (P = 0.022). GPi-DBS also results in a significant suppression of high β-γ PAC but without power modulation in either β sub-band (P = 0.008). Cortical high β-γ PAC is significantly correlated with severity of bradykinesia (Rho = 0.59, P = 0.045) and changes proportionally with therapeutic improvement (Rho = 0.61, P = 0.04).

conclusionsSimilar to STN-DBS, GPi-DBS reduces motor cortical β-γ PAC, like that also reported with dopaminergic mediations, suggesting it is a generalizable symptom biomarker in PD, independent of therapeutic target or proximity to the hyperdirect pathway.

Indexed as

Deep Brain StimulationAgedBeta RhythmCerebral CortexElectrocorticographyFemaleGamma RhythmGlobus PallidusHumansMaleMiddle AgedModels, NeurologicalMovementParkinson DiseaseDeep brain stimulationGlobus pallidus internusMotor cortexParkinson diseasePhase amplitude coupling

Identifiers

PMID29422442
PMCPMC5930048
OpenAlexW2790302671

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.