Evidence map›Paper›PMID 29422232›Full record

ArticleBlood cells, molecules & diseases2018

Combinations of antioxidants and/or of epigenetic enzyme inhibitors allow for enhanced collection of mouse bone marrow hematopoietic stem cells in ambient air.

Qingchun Cai, Maegan Capitano, Xinxin Huang, Bin Guo, Scott Cooper, Hal E Broxmeyer

Abstract read
In one paragraph

Article in Blood cells, molecules & diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Ex Vivo Expansion and Homing of Human Cord Blood Hematopoietic Stem Cells.Advances in experimental medicine and biology · 2023
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Long-Overdue Guidelines for the Cord Blood Banking Community.Stem cells translational medicine · 2019
    Article
  11. Review
  12. Article
  13. Enhancement of stem cell engraftment on a WHIM.The Journal of clinical investigation · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qingchun CaiDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Maegan CapitanoDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Xinxin HuangDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Bin GuoDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Scott CooperDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Hal E BroxmeyerDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: hbroxmey@iupui.edu.

Funding

Project-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7M
MECHANISMS OF SYNERGISTIC REGULATION OF STEM/PROGENITORSR01HL056416 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI BROXMEYER, HAL E. · 1996 to 2017
$6.0M
Controlling Influences of Oxygen Tension and CD26/DPP4 Enzymatic Activity on Regulation of Hematopoietic Stem/Progenitor Cells and Hematopoiesis During Health, Ageing, and DiseaseR35HL139599 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI BROXMEYER, HAL E. · 2018 to 2021
$3.1M
NHLBI NIH HHS R01 HL056416NHLBI NIH HHS R35 HL139599NIDDK NIH HHS U54 DK106846
6 · The paper itself

Abstract

Hematopoietic cell transplantation (HCT) is a treatment for malignant and non-malignant disorders. However, sometimes the numbers of donor hematopoietic stem cells (HSC) are limiting, which can compromise the success of HCT. We recently published that collection and processing of mouse bone marrow (BM) and human cord blood cells in a hypoxic atmosphere of 3% O

Indexed as

Hematopoietic Stem Cell MobilizationAnimalsAntioxidantsBone Marrow CellsColony-Forming Units AssayEnzyme InhibitorsEpigenesis, GeneticFemaleGraft SurvivalHematopoietic Stem CellsHematopoietic Stem Cell TransplantationHypoxiaMiceAntioxidantsEnzyme InhibitorsAntioxidantsEpigenetic enzyme inhibitorsHematopoietic stem cellHypoxia

Identifiers

PMID29422232
PMCPMC5940520

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.