Evidence map›Paper›PMID 29422091›Full record

Trial reportBMC pulmonary medicine2018

Effects of a partially supervised conditioning programme in cystic fibrosis: an international multi-centre randomised controlled trial (ACTIVATE-CF): study protocol.

Helge Hebestreit, Larry C Lands, Nancy Alarie, Jonathan Schaeff, Chantal Karila, David M Orenstein, Don S Urquhart, Erik H J Hulzebos, Lothar Stein, Christian Schindler and 3 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pulmonary medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01744561 (Effects of a Partially Supervised Conditioning Program in CF), which is not on this map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01744561 nacompletednot on this map

Effects of a Partially Supervised Conditioning Program in CF: an International Multi-centre, Randomized Controlled Trial

TypeinterventionalSponsorWuerzburg University HospitalRan2014 to 2018Enrolled155ConditionsCystic FibrosisArmsExercise Intervention
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Physical activity and exercise training in cystic fibrosis.The Cochrane database of systematic reviews · 2022
    Pooled it
  2. Exercise versus airway clearance techniques for people with cystic fibrosis.The Cochrane database of systematic reviews · 2022
    Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Exercise and Cystic Fibrosis.Advances in experimental medicine and biology · 2020
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Helge HebestreitPaediatric Department, Julius-Maximilians University, Josef-Schneider-Str. 2, 97080, Würzburg, Germany. hebestreit@uni-wuerzburg.de.
Larry C LandsMontreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada.
Nancy AlarieMontreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada.
Jonathan SchaeffPaediatric Department, Julius-Maximilians University, Josef-Schneider-Str. 2, 97080, Würzburg, Germany.
Chantal KarilaService de Pneumologie et Allergologie pédiatriques, Centre de Ressources et Compétences dans la Mucoviscidose, Hôpital Necker Enfants Malades, Université Paris V - Descartes, Paris, France.
David M OrensteinDepartment of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, USA.
Don S UrquhartDepartment of Paediatric Respiratory and Sleep Medicine, Royal Hospital for Sick Children, Edinburgh, UK.
Erik H J HulzebosChild Development & Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Lothar SteinHannover Medical School, Institute of Sports Medicine, Hannover, Germany.
Christian SchindlerSwiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland.
Susi KriemlerEpidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
Thomas RadtkeEpidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
ACTIVATE-CF Study Working Group

Funding

Association Vaincre la Mucoviscidose RC 20160501689/1/1/186Cystic Fibrosis Canada 2880Cystic Fibrosis Foundation no grant number availableEdinburgh Children's Hospital Charity 2013/14/24German Cystic Fibrosis Association (Mukoviszidose e.V.) 1402Mylan Healthcare GmbH not applicableNederlandse Cystic Fibrosis Stichting no grant number availableSwiss Society for Cystic Fibrosis (CFCH) no grant number availableThe Swiss National Science Foundation 320030_144175Vertex Innovation Award, Vertex Pharmaceuticals 2014-01
6 · The paper itself

Abstract

backgroundPhysical activity (PA) and exercise have become an accepted and valued component of cystic fibrosis (CF) care. Regular PA and exercise can positively impact pulmonary function, improve physical fitness, and enhance health-related quality of life (HRQoL). However, motivating people to be more active is challenging. Supervised exercise programs are expensive and labour intensive, and adherence falls off significantly once supervision ends. Unsupervised or partially supervised programs are less costly and more flexible, but compliance can be more problematic. The primary objective of this study is to evaluate the effects of a partially supervised exercise intervention along with regular motivation on forced expiratory volume in 1 s (FEV METHODS/

designIt is planned that a total of 292 patients with CF 12 years and older with a FEV DISCUSSION: This is the first large, international multi-centre study to investigate the effects of a PA intervention in CF with motivational feedback on several health outcomes using modern technology. Should this relatively simple programme prove successful, it will be made available on a wider scale internationally.

trial registrationClinicalTrials.gov Identifier: NCT01744561 ; Registration date: December 6, 2012.

Indexed as

AdolescentAnxietyBlood GlucoseChildCystic FibrosisDepressionExercise TherapyFeedbackForced Expiratory VolumeHumansMotivationPhysical Conditioning, HumanQuality of LifeBlood GlucoseCystic fibrosisExercise interventionPartially-supervisedPhysical activityRandomised controlled trial

Identifiers

PMID29422091
PMCPMC5806352

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.