ArticleRadiation oncology (London, England)2018
Early evaluation of radiation-induced parotid damage in patients with nasopharyngeal carcinoma by T2 mapping and mDIXON Quant imaging: initial findings.
Article in Radiation oncology (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 25 citations in OpenAlex.
- Simultaneous T1, T2, R2*, PDFF, and triglyceride quantification in the head and neck using magnetic resonance fingerprinting on a 1.5T MR-Linac.Medical physics · 2026Article
- Effect of meal ingestion on parotid gland T2 values.Radiological physics and technology · 2026Article
- Advanced magnetic resonance imaging techniques for structural and functional assessment of salivary glands.Radiology and oncology · 2026Review
- Diagnostic Value of T2 Mapping in Sacroiliitis Associated with Spondyloarthropathy.Diagnostics (Basel, Switzerland) · 2025Article
- Quantitative evaluation of parotid gland dysfunction in patients with hyposalivation using magnetic resonance imaging mapping technique : Quantification of Parotid gland function using MRI.BMC oral health · 2025Article
- Validation of quantitative magnetic resonance imaging techniques in head and neck healthy structures involved in the salivary and swallowing function: Accuracy and repeatability.Physics and imaging in radiation oncology · 2024Article
- Assessment of dental pulp response to caries via MR TBMC oral health · 2024Article
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- Assessment of hyperbaric oxygenation treatment response in parotid glands byRadiology and oncology · 2022Article
- Feasibility of DW-MRI analysis of salivary glands during head and neck radiotherapy.Technical innovations & patient support in radiation oncology · 2021Article
- Article
- The correlation between serum apolipoprotein B/apolipoprotein A1 ratio and brain necrosis in patients underwent radiotherapy for nasopharyngeal carcinoma.Brain and behavior · 2020Article
- Imaging for Response Assessment in Radiation Oncology: Current and Emerging Techniques.Hematology/oncology clinics of North America · 2020Review
- Study of the dose-volume parameters variation in tumor target volumes and organs at risk during nasopharyngeal carcinoma radiotherapy applying deformation registration.Translational cancer research · 2019Article
- Repetitive MRI of organs at risk in head and neck cancer patients undergoing radiotherapy.Clinical and translational radiation oncology · 2019Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundRadiation-induced parotid damage is a common complication in patients with nasopharyngeal carcinoma (NPC) treated with radiotherapy to head and neck region, which severely reduce the life quality of those patients. The aim of this study was to early evaluate the changes of irradiated parotid glands with T2 mapping and mDIXON Quant imaging.
methodsForty-one patients with NPC underwent conventional magnetic resonance imaging for nasopharynx and neck, and T2 mapping and mDIXON Quant imaging for bilateral parotid glands within 2 weeks before radiotherapy (pre-RT), 5 weeks after the beginning of radiotherapy (mid-RT), and 4 weeks after radiotherapy (post-RT). Parotid volume, T2 values, fat fraction (FF) values, and mean radiation dose were recorded and analyzed.
resultsFrom pre-RT to mid-RT, parotid volume decreased (atrophy rate, 27.0 ± 11.5%), while parotid T2 and FF values increased (change rate, 6.0 ± 6.2% for T2 value and 9.1 ± 9.9% for FF value) significantly. From mid-RT to post-RT, parotid T2 value continuously increased (change rate, 4.6 ± 7.7%), but parotid FF value decreased (change rate, - 9.9 ± 18.2%) significantly. Change rate of parotid T2 value significantly correlated with parotid atrophy rate from pre-RT to post-RT (r = 0.313, P = 0.027). Multiple linear regression analysis showed that parotid T2 value (standardized coefficient [SC] = - 0.259, P = 0.001) and FF value (SC = - 0.320, P = 0.014) negatively correlated with parotid volume, while parotid T2 value positively correlated with MR scan time point (SC = 0.476, P = 0.001) significantly. Parotid T2 and FF values showed excellent reproducibility (intraclass correlation coefficient, 0.935-0.992).
conclusionsT2 mapping and mDIXON Quant imaging is useful for noninvasive evaluation of radiation-induced parotid damage.
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