SynthesisEnvironmental health : a global access science source2018
Respiratory health effects of exposure to low levels of airborne endotoxin - a systematic review.
Synthesis in Environmental health : a global access science source, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 83 citations in OpenAlex.
- Indoor dust, immune activation, and household exposure risk after Hurricane Maria: a two-year pilot prospective cohort study in Puerto Rico.Journal of exposure science & environmental epidemiology · 2026Article
- Proteomic profiling reveals immunologic mediators of endotoxin-related lung function decline: a longitudinal prospective study in textile workers.Respiratory research · 2026Article
- Occupational exposure of goat farm workers to particulate matter and endotoxin.Annals of work exposures and health · 2026Article
- Article
- Shape of the association between endotoxin in school dust and children's lung function.ERJ open research · 2025Article
- Nasopharyngeal microbiota is influenced by agricultural air pollution in individuals with and without COPD.Scientific reports · 2025Article
- Associations between bioaerosols, lung function work-shift changes and inflammatory markers: A study of recycling workers.Scandinavian journal of work, environment & health · 2024Article
- Subchronic intranasal lipopolysaccharide exposure induces pulmonary autoimmunity and glomerulonephritis in NZBWF1 mice.Autoimmunity · 2024Article
- Bioaerosol Exposures and Respiratory Diseases in Cannabis Workers.Current allergy and asthma reports · 2024Review
- Ambient particle composition and toxicity in 31 major cities in China.Fundamental research · 2024Article
- Aconitate decarboxylase 1 mediates the acute airway inflammatory response to environmental exposures.Frontiers in immunology · 2024Article
- A Systematized Overview of Published Reviews on Biological Hazards, Occupational Health, and Safety.Safety and health at work · 2023Review
- Asthma and obesity: endotoxin another insult to add to injury?Clinical science (London, England : 1979) · 2021Review
- Correlation between levels of airborne endotoxin and heavy metals in subway environments in South Korea.Scientific reports · 2021Article
- Estimating Lung Deposition of Fungal Spores Using Actual Airborne Spore Concentrations and Physiological Data.Environmental science & technology · 2021Article
- Assessment of airborne endotoxin in sandstorm dust and indoor environments using a novel passive sampling device in Al Zulfi city, Saudi Arabia - Establishing threshold exposure levels.Saudi journal of biological sciences · 2021Article
- Tumor necrosis factor-α small interfering RNA alveolar epithelial cell-targeting nanoparticles reduce lung injury in C57BL/6J mice with sepsis.The Journal of international medical research · 2021Article
- Assessing Environmental Control Strategies in Cage-Free Egg Production Systems: Effect on Spatial Occupancy and Natural Behaviors.Animals : an open access journal from MDPI · 2020Article
- Characterization, pro-inflammatory response and cytotoxic profile of bioaerosols from urban and rural residential settings in Pune, India.Environmental pollution (Barking, Essex : 1987) · 2020Article
- Associations Between Bioaerosol Exposures and Lung Function Changes Among Dairy Workers in Colorado.Journal of occupational and environmental medicine · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundElevated endotoxin levels have been measured in ambient air around livestock farms, which is a cause of concern for neighbouring residents. There is clear evidence that occupational exposure to high concentrations of airborne endotoxin causes respiratory inflammation, respiratory symptoms and lung function decline. However, health effects of exposure to low levels of endotoxin are less well described. The aim of this systematic review is to summarize published associations between exposure to relatively low levels of airborne endotoxin and respiratory health endpoints.
methodsStudies investigating respiratory effects of measured or modelled exposure to low levels of airborne endotoxin (average < 100 EU/m
resultsTwenty-two included studies had a cross-sectional design, others were designed as longitudinal observational (n = 7) or experimental (n = 2) studies. Most studies (n = 23) were conducted in an occupational setting, some involved domestic or experimental exposure. Several studies reported statistically significant effects of exposure to low levels of endotoxin on respiratory symptoms and lung function. However, considerable heterogeneity existed in the outcomes of the included studies and no overall estimate could be provided by meta-analysis to quantify the possible relationship. Instead, a best evidence synthesis was performed among studies examining the exposure-response relationship between endotoxin and respiratory outcomes. Significant exposure-response relationships between endotoxin and symptoms and FEV
conclusionsRespiratory health effects of exposure to low levels of airborne endotoxin (< 100 EU/m
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.