Evidence map›Paper›PMID 29421749›Full record

ArticleChemosphere2018

Increased coiling frequency linked to apoptosis in the brain and altered thyroid signaling in zebrafish embryos (Danio rerio) exposed to the PBDE metabolite 6-OH-BDE-47.

Feng Wang, Mingliang Fang, David E Hinton, Melissa Chernick, Shenglan Jia, Yingdan Zhang, Lingtian Xie, Wenjing Dong, Wu Dong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemosphere, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. An ecotoxicological view on neurotoxicity assessment.Environmental sciences Europe · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Feng WangInner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, Collage of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, 028000, China.
Mingliang FangSchool of Civil and Environmental Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
David E HintonNicholas School of the Environment, Duke University, Durham, NC, 27708, United States.
Melissa ChernickNicholas School of the Environment, Duke University, Durham, NC, 27708, United States.
Shenglan JiaSchool of Civil and Environmental Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
Yingdan ZhangSchool of Civil and Environmental Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
Lingtian XieThe Environmental Research Institute, MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou, Guangdong, 510006, China.
Wenjing DongInner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, Collage of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, 028000, China.
Wu DongInner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, Collage of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, 028000, China; Nicholas School of the Environment, Duke University, Durham, NC, 27708, United States. Electronic address: dongwu@imun.edu.cn.
Inner Mongolia University for Nationalities · CNNanyang Technological University · SGDuke University · USSouth China Normal University · CN

Funding

Zebrafish as a Detector of Organophosphate ExposureP42ES010356 · NIEHS · DUKE UNIVERSITY · PI EDWARD D LEVIN · 2000 to 2026
$56.2M
NIEHS NIH HHS P42 ES010356
6 · The paper itself

Abstract

Polybrominated diphenyl ethers (PBDEs) are a group of brominated flame retardants that are ubiquitously detected in the environment and associated with adverse health outcomes. 6-OH-BDE-47 is a metabolite of the flame retardant, 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47), and there is increasing concern regarding its developmental neurotoxicity and endocrine disrupting properties. In this study, we report that early life exposure in zebrafish (Danio rerio) embryos to 6-OH-BDE-47 (50 and 100 nM) resulted in higher coiling frequency and significantly increased apoptotic cells in the brain. These effects were partially rescued by overexpression of thyroid hormone receptor β (THRβ) mRNA. Moreover, exposure to 100 nM 6-OH-BDE-47 significantly reduced the number of hypothalamic 5-hydroxytryptamine (5-HT, serotonin)-immunoreactive (5-HT-ir) neurons and the mRNA expression of tryptophan hydroxylase 2 (TPH2). These results indicate that 6-OH-BDE-47 affected thyroid hormone regulation through THRβ and negatively impacted the nervous system, in turn, affecting coiling behavior. Correlations of these endpoints suggest that coiling frequency could be used as an indicator of neurotoxicity in embryos.

Indexed as

AnimalsApoptosisEmbryo, NonmammalianEndocrine DisruptorsFlame RetardantsHalogenated Diphenyl EthersHypothalamusNeuronsPolybrominated BiphenylsSerotoninSignal TransductionThyroid GlandThyroid Hormone Receptors betaThyroid HormonesZebrafish2,2',4,4'-tetrabromodiphenyl ether6-OH-BDE-47Endocrine DisruptorsFlame RetardantsHalogenated Diphenyl Etherspentabromodiphenyl etherPolybrominated BiphenylsSerotoninThyroid Hormone Receptors betaThyroid Hormones5-Hydroxytryptamnine (serotonin, 5-HT)ApoptosisCoilingPolybrominated diphenyl ether (PBDE)Thyroid receptor (THRβ)Zebrafish

Identifiers

PMID29421749
PMCPMC7006228
OpenAlexW2792507105

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.