Evidence map›Paper›PMID 29421553›Full record

ArticleBiomaterials2018

Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis.

Xin Cui, Renee-Tyler Tan Morales, Weiyi Qian, Haoyu Wang, Jean-Pierre Gagner, Igor Dolgalev, Dimitris Placantonakis, David Zagzag, Luisa Cimmino, Matija Snuderl and 2 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 178 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
178citing papers in PubMed, 2 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

178 citing papers in PubMed, 2 syntheses or guidelines pooled it, 262 citations in OpenAlex.

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  6. Oncology letters · 2026
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118 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Xin CuiDepartment of Mechanical and Aerospace Engineering, New York University, Brooklyn, NY 11201, USA.
Renee-Tyler Tan MoralesDepartment of Mechanical and Aerospace Engineering, New York University, Brooklyn, NY 11201, USA.
Weiyi QianDepartment of Mechanical and Aerospace Engineering, New York University, Brooklyn, NY 11201, USA.
Haoyu WangDepartment of Mechanical and Aerospace Engineering, New York University, Brooklyn, NY 11201, USA.
Jean-Pierre GagnerDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA.
Igor DolgalevDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA.
Dimitris PlacantonakisDepartment of Neurosurgery, New York University School of Medicine, New York, NY 10016, USA.
David ZagzagDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA; Department of Neurosurgery, New York University School of Medicine, New York, NY 10016, USA.
Luisa CimminoDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA.
Matija SnuderlDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA.
Raymond H W LamDepartment of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong. Electronic address: rhwlam@cityu.edu.hk.
Weiqiang ChenDepartment of Mechanical and Aerospace Engineering, New York University, Brooklyn, NY 11201, USA. Electronic address: wchen@nyu.edu.
New York University · USCity University of Hong Kong · HK

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1M
Inverted two photon laser scanning microscope for host defenseS10RR023704 · NCRR · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DUSTIN, MICHAEL LORAN · 2008 to 2008
$500k
NCI NIH HHS P30 CA016087NCRR NIH HHS S10 RR023704
6 · The paper itself

Abstract

Glioblastoma (GBM) is the most lethal primary adult brain tumor and its pathology is hallmarked by distorted neovascularization, diffuse tumor-associated macrophage infiltration, and potent immunosuppression. Reconstituting organotypic tumor angiogenesis models with biomimetic cell heterogeneity and interactions, pro-/anti-inflammatory milieu and extracellular matrix (ECM) mechanics is critical for preclinical anti-angiogenic therapeutic screening. However, current in vitro systems do not accurately mirror in vivo human brain tumor microenvironment. Here, we engineered a three-dimensional (3D), microfluidic angiogenesis model with controllable and biomimetic immunosuppressive conditions, immune-vascular and cell-matrix interactions. We demonstrate in vitro, GL261 and CT-2A GBM-like tumors steer macrophage polarization towards a M2-like phenotype for fostering an immunosuppressive and proangiogenic niche, which is consistent with human brain tumors. We distinguished that GBM and M2-like immunosuppressive macrophages promote angiogenesis, while M1-like pro-inflammatory macrophages suppress angiogenesis, which we coin "inflammation-driven angiogenesis." We observed soluble immunosuppressive cytokines, predominantly TGF-β1, and surface integrin (α

Indexed as

AnimalsBrain NeoplasmsCell Line, TumorExtracellular MatrixGlioblastomaMacrophagesMiceMicroscopy, ConfocalNeovascularization, PathologicRAW 264.7 CellsSignal TransductionAngiogenesisECMEndothelial-macrophage interactionGlioblastoma

Identifiers

PMID29421553
PMCPMC8059366
OpenAlexW2794101039

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.