ReviewFrontiers in neuroendocrinology2018
Behavioral and structural adaptations to stress.
Review in Frontiers in neuroendocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- The association between procrastination and negative emotions in healthy individuals: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Intergenerational Associations of Childhood War Exposure, Adverse Childhood Experiences, and Mental Health in Offspring of Lebanese Immigrants.Journal of immigrant and minority health · 2026Article
- Stress, needs, and behaviour: understanding chronic stress in pet domestic dogs (Canis lupus familiaris) from the prism of needs.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Sex and stress paradigm influence behavioural, neuroimmune, and microbiome responses in pubertal CD-1 mice.Brain, behavior, & immunity - health · 2026Article
- The Effect of Workplace Pressure and Experience on Burnout in Embryologists Working in Assisted Reproduction in Spain.International journal of environmental research and public health · 2026Article
- Stress during the first 1,000 days of life in humans, when everything begins.Frontiers in human neuroscience · 2026Review
- Adverse Childhood Experiences Underlie Race-Related Differences in Neural Reactivity to Stress.Behavioural neurology · 2026Article
- High-fructose diet induces depressive-like behaviors and short-term memory deficits through hippocampal neurogenesis impairment via neural stem cell dysfunction.Nutrition & metabolism · 2025Article
- The allostatic triage model of psychopathology (ATP Model): How reallocation of brain energetic resources under stress elicits psychiatric symptoms.Neuroscience and biobehavioral reviews · 2025Review
- Treadmill exercise alleviates depression in female mice induced by chronic unpredictable mild stress through the Inhibition of cGAS-STING signalling.Scientific reports · 2025Article
- Exploring the Link Between Stress and Working Memory in Adults.International journal of environmental research and public health · 2025Article
- Pharmacological interventions targeting β-adrenoceptors in colorectal cancer: an evolving paradigm.Inflammopharmacology · 2025Review
- Beyond the Surface: Investigating the Potential Mechanisms of Non-Motor Symptoms in Myasthenia Gravis.European journal of neurology · 2025Review
- Understanding the interplay between stress, anxiety, and depression and their impact on health in traffic police officers.Frontiers in psychiatry · 2025Article
- Embryonic heat conditioning induces paternal heredity of immunological cross- tolerance: coordinative role of CpG DNA methylation and miR-200a regulation.Frontiers in immunology · 2025Article
- Intricate mechanism of anxiety disorder, recognizing the potential role of gut microbiota and therapeutic interventions.Metabolic brain disease · 2024Review
- Gut-Microbiota-Derived Butyric Acid Overload Contributes to Ileal Mucosal Barrier Damage in Late Phase of Chronic Unpredictable Mild Stress Mice.International journal of molecular sciences · 2024Article
- High and low current perceived stress associated with enhanced emotional mnemonic discrimination.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Electroacupuncture alleviates the relapse of pain-related aversive memory by activating KOR and inhibiting GABAergic neurons in the insular cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Mechanisms underlying the effect of voluntary running on adult hippocampal neurogenesis.Hippocampus · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Unpredictable aversive experiences, or stressors, lead to changes in depression- and anxiety-related behavior and to changes in hippocampal structure including decreases in adult neurogenesis, granule cell and pyramidal cell dendritic morphology, and volume. Here we review the relationship between these behavioral and structural changes and discuss the possibility that these changes may be largely adaptive. Specifically, we suggest that new neurons in the dentate gyrus enhance behavioral adaptability to changes in the environment, biasing behavior in novel situations based on previous experience with stress. Conversely, atrophy-like changes in the hippocampus and decreased adult neurogenesis following chronic stress may serve to limit stress responses and stabilize behavior during chronic stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.