Evidence map›Paper›PMID 29420849›Full record

ArticleHepatology (Baltimore, Md.)2018

Expression of microRNA-155 in inflammatory cells modulates liver injury.

Delia Blaya, Beatriz Aguilar-Bravo, Fengjie Hao, Silvia Casacuberta-Serra, Mar Coll, Luis Perea, Júlia Vallverdú, Isabel Graupera, Elisa Pose, Laura Llovet and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Hepatology (Baltimore, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Non-coding RNAs in alcohol-associated liver disease.Liver research (Beijing, China) · 2025
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  20. The antimicrobial peptide YD attenuates inflammationActa pharmaceutica Sinica. B · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Delia BlayaLaboratory of Liver Cell Plasticity and Tissue Repair, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS).
Beatriz Aguilar-BravoLaboratory of Liver Cell Plasticity and Tissue Repair, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS).
Fengjie HaoDepartment of Immunology, Complutense University School of Medicine.
Silvia Casacuberta-SerraGene and Cell Therapy Laboratory, Vall d'Hebron Institut de Recerca.
Mar CollLaboratory of Liver Cell Plasticity and Tissue Repair, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS).
Luis PereaLaboratory of Liver Cell Plasticity and Tissue Repair, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS).
Júlia VallverdúLaboratory of Liver Cell Plasticity and Tissue Repair, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS).
Isabel GrauperaLaboratory of Liver Cell Plasticity and Tissue Repair, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS).
Elisa PoseLaboratory of Liver Cell Plasticity and Tissue Repair, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS).
Laura LlovetCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.
Jordi BarquineroGene and Cell Therapy Laboratory, Vall d'Hebron Institut de Recerca.
Francisco Javier CuberoDepartment of Immunology, Complutense University School of Medicine.
Juan CaballeríaLaboratory of Liver Cell Plasticity and Tissue Repair, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS).
Pere GinèsLaboratory of Liver Cell Plasticity and Tissue Repair, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS).
Pau Sancho-BruLaboratory of Liver Cell Plasticity and Tissue Repair, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS).
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESHospital Clínic de Barcelona · ESUniversidad Complutense de Madrid · ESVall d'Hebron Institut de Recerca · ES

Funding

Molecular Subtypes for Targeted Therapies in Alcoholic HepatitisU01AA021908 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BATALLER, RAMON · 2013 to 2017
$6.0M
MIF in progression and treatment of ALDU01AA020821 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI NAGY, LAURA E. · 2012 to 2016
$2.1M
NIAAA NIH HHS U01 AA020821NIAAA NIH HHS U01 AA021908
6 · The paper itself

Abstract

MicroRNA 155 (miR-155) is involved in immune and inflammatory diseases and is associated with liver fibrosis and steatohepatitis. However, the mechanisms involved in miR-155 regulation of liver injury are largely unknown. The role of miR-155 in acute liver injury was assessed in wild-type (WT), miR-155

conclusionmiR-155 expression is altered in both liver tissue and circulating inflammatory cells during liver injury, thus regulating inflammatory cell recruitment and liver damage; these results suggest that maintaining miR-155 expression in inflammatory cells might be a potential strategy to modulate liver injury. (Hepatology 2018).

Indexed as

AdultAgedAnimalsConcanavalin ACytokinesFemaleHepatitis, AutoimmuneHepatocytesHumansLiverLiver DiseasesMaleMiceMice, KnockoutMicroRNAsMiddle AgedConcanavalin ACytokinesMicroRNAsMIRN155 microRNA, humanMirn155 microRNA, mouse

Identifiers

PMID29420849
PMCPMC6082738
OpenAlexW2793376808

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.