ArticlePloS one2018
Immunophenotypic characterization of human T cells after in vitro exposure to different silicone breast implant surfaces.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- Advances in Silicone Implants Characterization: A Comprehensive Overview of Chemical, Physical and Biological Methods for Biocompatibility Assessment.Bioengineering (Basel, Switzerland) · 2025Review
- Biologic Response With and Without Acellular Dermal Matrix in Breast Reconstruction.Plastic and reconstructive surgery. Global open · 2025Article
- Silicone breast implant-associated pathologies and T cell-mediated responses.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Unraveling the Immune Web: Advances in SMI Capsular Fibrosis from Molecular Insights to Preclinical Breakthroughs.Biomolecules · 2024Review
- SMI-Capsular Fibrosis and Biofilm Dynamics: Molecular Mechanisms, Clinical Implications, and Antimicrobial Approaches.International journal of molecular sciences · 2024Review
- Exploring Senolytic and Senomorphic Properties of Medicinal Plants for Anti-Aging Therapies.International journal of molecular sciences · 2024Article
- Implant Texture and Capsular Contracture: A Review of Cellular and Molecular Pathways.Plastic and reconstructive surgery. Global open · 2024Article
- Human T-Cell Responses to Metallic Ion-Doped Bioactive Glasses.International journal of molecular sciences · 2024Article
- Surface Topography, Microbial Adhesion, and Immune Responses in Silicone Mammary Implant-Associated Capsular Fibrosis.International journal of molecular sciences · 2024Article
- Silicone implant surface microtopography modulates inflammation and tissue repair in capsular fibrosis.Frontiers in immunology · 2024Article
- Implant-based breast surgery and capsular formation: when, how and why?-a narrative review.Annals of translational medicine · 2023Review
- Is It All about Surface Topography? An Intra-Individual Clinical Outcome Analysis of Two Different Implant Surfaces in Breast Reconstruction.Journal of clinical medicine · 2023Article
- Quantitative Proteomic Characterization of Foreign Body Response towards Silicone Breast Implants Identifies Chronological Disease-Relevant Biomarker Dynamics.Biomolecules · 2023Article
- Updates in pathobiological aspects of anaplastic large cell lymphoma.Frontiers in oncology · 2023Review
- What are the likely causes of breast implant associated anaplastic large cell lymphoma (BIA-ALCL)?JPRAS open · 2022Review
- The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans.Nature biomedical engineering · 2021Article
- Surgical Treatment of Capsular Contracture (CC): Literature Review and Outcomes Utilizing Implants in Revisionary Surgery.Aesthetic plastic surgery · 2021Review
- Functionalization of Silicone Surface with Drugs and Polymers for Regulation of Capsular Contracture.Polymers · 2021Review
- Response to: Nano-Surface Implants: Indications and Limitations.Aesthetic surgery journal · 2021Article
- Four-Year Interim Results of the Safety of Augmentation Mammaplasty Using the Motiva Ergonomix™ Round SilkSurface: A Multicenter, Retrospective Study.Aesthetic plastic surgery · 2021Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most common complication of silicone breast implants is capsular contracture (massive scar formation around the implant). We postulate that capsular contracture is always a sequel to inflammatory processes, with both innate and adaptive immune mechanisms participating. In general, fibroblasts and macrophages have been used as cell types to evaluate in vitro the biocompatibility of breast implant surfaces. Moreover, also T cells have been found at the implant site at the initial stage of fibrous capsule formation. However, only few studies have addressed the influence of surfaces with different textures on T-cell responses. The aim of the present study was to investigate the immune response of human peripheral blood mononuclear cells (PBMC) to commercially available silicone breast implants in vitro. PBMC from healthy female blood donors were cultured on each silicone surface for 4 days. Proliferation and phenotype of cultured cells were assessed by flow cytometry. Cytokine levels were determined by multiplex and real-time assay. We found that silicone surfaces do not induce T-cell proliferation, nor do they extensively alter the proportion of T cell subsets (CD4, CD8, naïve, effector memory). Interestingly, cytokine profiling identified matrix specific differences, especially for IL-6 and TNF-α on certain surface topographies that could lead to increased fibrosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.