ArticlePloS one2018
Controlled hypothermia may improve surfactant function in asphyxiated neonates with or without meconium aspiration syndrome.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Effect of therapeutic hypothermia on surfactant proteins, anti-inflammatory and pro-fibrotic mediators.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Airway allergy causes alveolar macrophage death, profound alveolar disorganization and surfactant dysfunction.Frontiers in immunology · 2023Article
- Severe Hypercapnia Requiring 48-h Whole-Body Hypothermia in an Infant with Acute Bronchiolitis.Children (Basel, Switzerland) · 2022Article
- Strategies to protect surfactant and enhance its activity.Biomedical journal · 2021Review
- The International Week of Surfactant Research: Increasing knowledge about surfactant and unexploited opportunities.Biomedical journal · 2021Article
- Techniques to evaluate surfactant activity for a personalized therapy of RDS neonates.Biomedical journal · 2021Review
- Article
- Molecular and biophysical mechanisms behind the enhancement of lung surfactant function during controlled therapeutic hypothermia.Scientific reports · 2021Article
- Vitamin E acetate as linactant in the pathophysiology of EVALI.Medical hypotheses · 2020Article
- Telomerase treatment prevents lung profibrotic pathologies associated with physiological aging.The Journal of cell biology · 2020Article
- Respiratory management during therapeutic hypothermia for hypoxic-ischemic encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2019Review
- Inhibition and counterinhibition of Surfacen, a clinical lung surfactant of natural origin.PloS one · 2018Article
- Quantitative lung ultrasound to understand pathophysiology and guide surfactant therapy in neonates with meconium aspiration.Jornal de pediatriaArticle
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Authors and funding
4 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhole-body hypothermia (WBH) is used to improve neurological outcomes in perinatal asphyxia. Recent studies suggested a beneficial effect of hypothermia for some types of acute respiratory failure. However, no data are available about the biophysical function of human surfactant during WBH. We investigated whether WBH improves surfactant biophysical properties in asphyxiated neonates with or without meconium aspiration syndrome (MAS).
methodsNon-bronchoscopic bronchoalveolar lavage (BAL) has been collected from 10 asphyxiated neonates (2 with MAS, 8 with no lung disease (NLD)) at different time-points (pre-WBH, 24h, 48h, 72h of WBH and post-WBH). Surfactant was extracted and tested by captive bubble surfactometry (CBS) in triplicate, at 37°C and 33.5°C, through initial adsorption and dynamic compression-expansion cycling. Phosphatidylcholine and cholesterol were assayed using enzymatic methods. Clinical data were recorded in real-time.
resultsMinimum surface tension under dynamic testing was significantly improved as assessed at 33.5°C compared with its behavior at 37°C in NLD neonates: the difference was evident after at least 72h of WBH and remained significant at 6h after rewarming (72h: p = 0.009; rewarming: p = 0.040). Similar results were obtained in MAS patients whose surfactant activity improved already at 48h of hypothermia. Total cholesterol showed a trend to increase at the first 24-48h of hypothermia in NLD patients. Conversely, hypothermia seemed to reduce the excess of exogenous cholesterol in MAS surfactant.
conclusionsSurfactant biophysical properties may improve after 48-72h of WBH in asphyxiated neonates and the improvement is maintained shortly after rewarming. Due to study limitations, further studies are warranted to better clarify the effects of hypothermia on surfactant activity.
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