ArticlePLoS genetics2018
Drosophila Gr64e mediates fatty acid sensing via the phospholipase C pathway.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- A systematic review of the biological mediators of fat taste and smell.Physiological reviews · 2023Pooled it
- Gustatory avoidance of fatty acids byProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dietary salt induces taste desensitization via receptor internalization in Drosophila in a sexually dimorphic manner.Molecules and cells · 2025Article
- An evolutionarily conserved cation channel tunes the sensitivity of gustatory neurons to ephaptic inhibition inProceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Tastant-receptor interactions: insights from the fruit fly.Frontiers in nutrition · 2024Review
- The power of Drosophila genetics in studying insect toxicology and chemical ecology.Crop health · 2023Review
- Acid and Alkali Taste Sensation.Metabolites · 2023Review
- Evolution of fatty acid taste in drosophilids.Cell reports · 2023Article
- Molecular Basis of Hexanoic Acid Taste inMolecules and cells · 2023Article
- The taste of vitamin C in Drosophila.EMBO reports · 2023Article
- Molecular sensors in the taste system of Drosophila.Genes & genomics · 2023Review
- Oxalic Acid Inhibits Feeding Behavior of the Brown Planthopper via Binding to Gustatory Receptor Gr23a.Cells · 2023Article
- Taste adaptations associated with host specialization in the specialist Drosophila sechellia.The Journal of experimental biology · 2023Article
- Article
- Bacteria-Derived Peptidoglycan Triggers a Noncanonical Nuclear Factor-κB-Dependent Response inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The Gr64 cluster of gustatory receptors promotes survival and proteostasis of epithelial cells in Drosophila.PLoS biology · 2022Article
- Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animals use taste to sample and ingest essential nutrients for survival. Free fatty acids (FAs) are energy-rich nutrients that contribute to various cellular functions. Recent evidence suggests FAs are detected through the gustatory system to promote feeding. In Drosophila, phospholipase C (PLC) signaling in sweet-sensing cells is required for FA detection but other signaling molecules are unknown. Here, we show Gr64e is required for the behavioral and electrophysiological responses to FAs. GR64e and TRPA1 are interchangeable when they act downstream of PLC: TRPA1 can substitute for GR64e in FA but not glycerol sensing, and GR64e can substitute for TRPA1 in aristolochic acid but not N-methylmaleimide sensing. In contrast to its role in FA sensing, GR64e functions as a ligand-gated ion channel for glycerol detection. Our results identify a novel FA transduction molecule and reveal that Drosophila Grs can act via distinct molecular mechanisms depending on context.
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