Evidence map›Paper›PMID 29420478›Full record

ArticleNature2018

Dynamic basis for dG•dT misincorporation via tautomerization and ionization.

Isaac J Kimsey, Eric S Szymanski, Walter J Zahurancik, Anisha Shakya, Yi Xue, Chia-Chieh Chu, Bharathwaj Sathyamoorthy, Zucai Suo, Hashim M Al-Hashimi

Abstract read
In one paragraph

Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed.

  1. Article
  2. Article
  3. Slow PPThe Journal of biological chemistry · 2026
    Article
  4. Article
  5. Nature communications · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Surface-Accelerated String Method for Locating Minimum Free Energy Paths.Journal of chemical theory and computation · 2024
    Article
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Isaac J KimseyDepartment of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.
Eric S SzymanskiDepartment of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.
Walter J ZahurancikDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.
Anisha ShakyaDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.
Yi XueDepartment of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.
Chia-Chieh ChuDepartment of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.
Bharathwaj SathyamoorthyDepartment of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.
Zucai SuoDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.
Hashim M Al-HashimiDepartment of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.

Funding

The Center for HIV RNA Studies (CRNA)P50GM103297 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAYIE, KWAKU · 2012 to 2016
$21.7M
Time-resolved small angle X-ray scatteringP01GM066275 · NIGMS · STANFORD UNIVERSITY · PI HERSCHLAG, DANIEL · 2003 to 2017
$17.8M
Role of DNA structural dynamics in mutagenesis and oncogenesisR01GM089846 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Hashim M Al-Hashimi · 2010 to 2026
$5.2M
NIGMS NIH HHS P01 GM066275NIGMS NIH HHS P50 GM103297NIGMS NIH HHS R01 GM089846
6 · The paper itself

Abstract

Tautomeric and anionic Watson-Crick-like mismatches have important roles in replication and translation errors through mechanisms that are not fully understood. Here, using NMR relaxation dispersion, we resolve a sequence-dependent kinetic network connecting G•T/U wobbles with three distinct Watson-Crick mismatches: two rapidly exchanging tautomeric species (G

Indexed as

Base Pair MismatchDNA ReplicationMutagenesisAnimalsAnionsDNADNA-Directed DNA PolymeraseGuanineHumansHydrogen-Ion ConcentrationKineticsMagnetic Resonance SpectroscopyProbabilityRatsThymineAnionsDNADNA-Directed DNA PolymeraseGuanineThymine

Identifiers

PMID29420478
PMCPMC5808992

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.