ArticleScience (New York, N.Y.)2018
Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 714 papers.
0numbers the graph read from it
0cells of the map it votes in
714citing papers in PubMed
72.8field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
714 citing papers in PubMed, 1,074 citations in OpenAlex.
- The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial.Cancer prevention research (Philadelphia, Pa.) · 2025Trial
- The Association of Gut Microbiota With TRPM7 Genotype, Colorectal Polyps, and Magnesium.The Journal of nutrition · 2025Trial
- Functionally declining microbiota in chronic disease: beyond taxonomic loss.Gut microbes · 2026Review
- Gut microbiota and diet in colorectal cancer: Converging determinants of carcinogenesis.Gut microbes · 2026Review
- Emergence of invasiveGut microbes · 2026Article
- Altered crosstalk of bacterial lipopolysaccharide with immune cells in colorectal cancer compared to paired adjacent intestinal tissue.Gut microbes · 2026Article
- Colorectal cancer landscape from gut microbiota: Insights into mutations, epigenetic dysregulation, and immune microenvironment alterations.Virulence · 2026Review
- Intratumoral microbiota in cancer immunotherapy: metabolic-epigenetic crosstalk and engineered bacterial therapeutics.Experimental hematology & oncology · 2026Review
- Gut Microbial Metabolism Inactivates Trifluridine and Drives Loss of Anticancer Efficacy.ACS pharmacology & translational science · 2026Article
- Shaping the future of early-onset colorectal cancer prevention.Nature reviews. Cancer · 2026Review
- Fusobacterium nucleatum enhances enterotoxigenic Bacteroides fragilis-mediated neuron loss and intestinal motility dysfunction.Nature microbiology · 2026Article
- Association between Clostridium septicum and Streptococcus gallolyticus bacteremia and colorectal neoplasms.Surgery today · 2026Article
- Intratumoral microbiota in the growth of CRC and lung cancer: Comprehensive insights from etiology to therapy.iScience · 2026Review
- Integrating germline and tumor sequencing to improve hereditary cancer diagnosis and care.European journal of human genetics : EJHG · 2026Review
- Clinical applications of gut microbiome for non-invasive diagnosis of colorectal neoplasia.Journal of gastroenterology · 2026Article
- Combining genotoxic gut bacterial strains increases tumor burden and accelerates onset in a germ-free mouse model of colon carcinogenesis.Cell reports · 2026Article
- Lactobacillus strains in the prevention and disruption of antimicrobial-resistance in pathogenic microbial biofilms: a review of mechanisms and clinical perspective.Folia microbiologica · 2026Review
- Intra-tumoral microbiota: Key modulators of tumor immunity and therapeutic potential.Genes & diseases · 2026Review
- Stage-Specific carcinogenic mechanisms and intervention strategies for pksArchives of microbiology · 2026Review
- Spatial Heterogeneity of Intratumoral Microbiota and Its Roles in Tumor-Microbiota Interactions and Therapeutic Implications.Pathogens (Basel, Switzerland) · 2026Review
654 more citing papers are in PubMed but not listed here.
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Authors and funding
18 authors at 3 institutions in 2 countries.
Christine M DejeaBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.
Payam FathiBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.
John M CraigDepartment of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-7445-1053
Annemarie BoleijBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-4495-5880
Rahwa TaddeseDepartment of Pathology, Radboud University Medical Center, Postbus 9101, 6500 HB Nijmegen, Netherlands.ORCID 0000-0002-4516-6050
Abby L GeisBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-3659-5734
Xinqun WuBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-4661-799X
Christina E DeStefano ShieldsBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-4714-3423
Elizabeth M HechenbleiknerDepartment of Surgery, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-0706-7860
David L HusoDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD, USA.
Robert A AndersDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Francis M GiardielloDepartment of Oncology, Johns Hopkins University, Baltimore, MD, USA.
Elizabeth C WickDepartment of Surgery, Johns Hopkins University, Baltimore, MD, USA.
Hao WangBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.
Shaoguang WuBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.
Drew M PardollBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.
Franck HousseauBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-7028-3953
Cynthia L SearsBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA. csears@jhmi.edu.ORCID 0000-0003-4059-1661
Bloomberg (United States) · USJohns Hopkins University · USRadboud University Nijmegen · NL
Funding
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6MTumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI LENNON, ANNE MARIE · 1993 to 2022
$54.6MTranslational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ZACHOS, NICHOLAS CONSTANTINE · 2011 to 2020
$12.0MClinical and Laboratory Research Training for Surgical OncologistsT32CA126607 · NCI · JOHNS HOPKINS UNIVERSITY · PI CAMERON, ANDREW M. · 2008 to 2024
$6.0MEnterotoxigenic Bacteroides fragilis: A bacterial promoter of colon oncogenesisR01CA151393 · NCI · JOHNS HOPKINS UNIVERSITY · PI PARDOLL, DREW M., SEARS, CYNTHIA · 2010 to 2014
$2.7MRole of Stat3 in Colonic InflammationK08DK087856 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WICK, ELIZABETH C · 2010 to 2014
$788kNCI NIH HHS P30 CA006973NCI NIH HHS P50 CA062924NCI NIH HHS R01 CA151393NCI NIH HHS T32 CA126607NIDDK NIH HHS K08 DK087856NIDDK NIH HHS P30 DK089502
Abstract
Individuals with sporadic colorectal cancer (CRC) frequently harbor abnormalities in the composition of the gut microbiome; however, the microbiota associated with precancerous lesions in hereditary CRC remains largely unknown. We studied colonic mucosa of patients with familial adenomatous polyposis (FAP), who develop benign precursor lesions (polyps) early in life. We identified patchy bacterial biofilms composed predominately of
Indexed as
BiofilmsCarcinogenesisAdenomatous Polyposis ColiAnimalsBacterial ToxinsBacteroides fragilisColonColonic NeoplasmsDNA DamageEscherichia coliGastrointestinal MicrobiomeHumansInterleukin-17Intestinal MucosaMetalloendopeptidasesMiceBacterial ToxinsBacteroides fragilis toxincolibactinIL17A protein, humanInterleukin-17MetalloendopeptidasesPeptidesPolyketides
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.