Evidence map›Paper›PMID 29420292›Full record

ArticleScience (New York, N.Y.)2018

The piRNA targeting rules and the resistance to piRNA silencing in endogenous genes.

Donglei Zhang, Shikui Tu, Michael Stubna, Wei-Sheng Wu, Wei-Che Huang, Zhiping Weng, Heng-Chi Lee

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed
50.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 262 citations in OpenAlex.

  1. DivergenteLife · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. AbioRxiv : the preprint server for biology · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. piRNAs safeguard splicing and RNA fidelity during heat shock.bioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. piENOX2 regulates ALKBH5-mediated Itga4 mExperimental & molecular medicine · 2025
    Article
  18. Article
  19. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Article

86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Donglei ZhangDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-2720-1414
Shikui TuProgram in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.ORCID 0000-0001-6270-0449
Michael StubnaDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-4950-9273
Wei-Sheng WuDepartment of Electrical Engineering, National Cheng Kung University, Tainan, Taiwan.ORCID 0000-0002-9919-9579
Wei-Che HuangDepartment of Electrical Engineering, National Cheng Kung University, Tainan, Taiwan.
Zhiping WengProgram in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.ORCID 0000-0002-3032-7966
Heng-Chi LeeDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA. hengchilee@uchicago.edu.ORCID 0000-0001-8154-906X
University of Chicago · USNational Cheng Kung University · TWUniversity of Massachusetts Chan Medical School · US

Funding

Understanding the architecture, regulation, and function of piRNA-producing genesP01HD078253 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ZAMORE, PHILLIP D · 2015 to 2019
$6.5M
Mechanism of piRNA-mediated recognition and silencing of foreign genesR00GM108866 · NIGMS · UNIVERSITY OF CHICAGO · PI LEE, HENG-CHI · 2016 to 2018
$747k
Mechanism of piRNA-mediated recognition and silencing of foreign genesK99GM108866 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LEE, HENG-CHI · 2014 to 2015
$126k
NICHD NIH HHS P01 HD078253NIGMS NIH HHS K99 GM108866NIGMS NIH HHS R00 GM108866
6 · The paper itself

Abstract

Piwi-interacting RNAs (piRNAs) silence transposons to safeguard genome integrity in animals. However, the functions of the many piRNAs that do not map to transposons remain unknown. Here, we show that piRNA targeting in

Indexed as

Gene SilencingAnimalsCaenorhabditis elegansCDC2 Protein KinaseGene TargetingGreen Fluorescent ProteinsRNA, HelminthRNA, Small InterferingTransgenesCDC2 Protein KinaseGreen Fluorescent ProteinsRNA, HelminthRNA, Small Interfering

Identifiers

PMID29420292
PMCPMC5939965
OpenAlexW2787719063

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.