ArticleScience (New York, N.Y.)2018
Open access · bronzeAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 2 pooled it
14.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 2 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- Leveraging pleiotropy identifies common-variant associations with selective IgA deficiency.Clinical immunology (Orlando, Fla.) · 2024Pooled it
- PROM1 and PROM2 expression differentially modulates clinical prognosis of cancer: a multiomics analysis.Cancer gene therapy · 2020Pooled it
- Cell-type specific analyses in blood and gut identify cis-eQTL matching 140 IBD risk loci and entrectinib as repurposing candidate.Nature communications · 2026Article
- 5-OH-TMT mitigates colitis through HTRA2 binding-mediated activation of the Dectin-1 signaling pathway.Acta pharmacologica Sinica · 2026Article
- Harnessing the gut-immune-joint axis: Oral microalgae-based thermoresponsive microspheres enhance intra-articular therapy for rheumatoid arthritis.Bioactive materials · 2026Article
- Associations of non-HLA gene polymorphisms with celiac disease in India.Scientific reports · 2026Article
- Monogenic forms of inflammatory bowel disease: Genetic mechanisms, models, and clinical implications.Molecular medicine (Cambridge, Mass.) · 2026Review
- PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation.Nature communications · 2025Article
- Gene-environment interactions shape the host-microbial interface in inflammatory bowel disease.Nature immunology · 2025Review
- The INAVA mRNA in Extracellular Vesicles Activates Normal Ovarian Fibroblasts by Phosphorylation-Ubiquitylation Crosstalk of HMGA2.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Exploring the genetic basis between inflammatory bowel disease and venous thromboembolism.Thrombosis journal · 2025Article
- Shared Genetics in Celiac Disease and Inflammatory Bowel Disease Specify a Greater Role for Intestinal Epithelial Cells.International journal of molecular sciences · 2025Review
- Inflammatory bowel disease risk gene C1ORF106 regulates actin dynamics in intestinal epithelial cells.bioRxiv : the preprint server for biology · 2025Article
- Elevated SPARC Disrupts the Intestinal Barrier Integrity in Crohn's Disease by Interacting with OTUD4 and Activating the MYD88/NF-κB Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Eleven Grand Challenges for Inflammatory Bowel Disease Genetics and Genomics.Inflammatory bowel diseases · 2025Review
- Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease.Cellular and molecular life sciences : CMLS · 2024Article
- Article
- Challenges in IBD Research 2024: Preclinical Human IBD Mechanisms.Inflammatory bowel diseases · 2024Review
- Genetic mapping across autoimmune diseases reveals shared associations and mechanisms.Nature genetics · 2024Article
- Sirt2 inhibition improves gut epithelial barrier integrity and protects mice from colitis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
19 authors at 4 institutions in 2 countries.
Vishnu MohananThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-1314-7090
Toru NakataThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0003-3678-4807
A Nicole DeschThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0001-7425-5792
Chloé LévesqueMontreal Heart Institute Research Center, Montreal, Quebec H1T 1C8, Canada.
Angela BoroughsCenter for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-9701-9538
Gaelen GuzmanThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-7696-6034
Zhifang CaoCenter for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0003-3019-2763
Elizabeth CreaseyCenter for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-9724-7979
Junmei YaoCenter for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-4074-7761
Gabrielle BoucherMontreal Heart Institute Research Center, Montreal, Quebec H1T 1C8, Canada.
Guy CharronMontreal Heart Institute Research Center, Montreal, Quebec H1T 1C8, Canada.
Atul K BhanPathology Department, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Monica SchenoneThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-6456-8768
Steven A CarrThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-7203-4299
Hans-Christian ReineckerCenter for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA.
Mark J DalyThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-0949-8752
John D RiouxMontreal Heart Institute Research Center, Montreal, Quebec H1T 1C8, Canada.ORCID 0000-0001-7560-8326
Kara G LassenThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. klassen@broadinstitute.org xavier@molbio.mgh.harvard.edu.ORCID 0000-0001-7023-461X
Ramnik J XavierThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. klassen@broadinstitute.org xavier@molbio.mgh.harvard.edu.ORCID 0000-0002-5630-5167
Broad Institute · USMassachusetts General Hospital · USMontreal Heart Institute · CAHarvard University · US
Funding
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MGenetic and Pathway Analysis CoreU19AI109725 · NIAID · WASHINGTON UNIVERSITY · PI ALLEN, PAUL M · 2014 to 2018
$32.7MUniversite de Montreal IBD Genetics Research CenterU01DK062432 · NIDDK · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI John D. Rioux · 2002 to 2026
$9.6MIdentification of the IBD genes on chromosomes 3p and 6pR01DK064869 · NIDDK · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI RIOUX, JOHN D. · 2003 to 2016
$7.8MInnate Immune Defense Mechanisms in the IntestineR01AI113333 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI REINECKER, HANS-CHRISTIAN · 2014 to 2025
$5.7MAntigen Recognition at Intestinal Epithelial InterphasesR01DK068181 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI REINECKER, HANS-CHRISTIAN · 2005 to 2017
$5.2MIL-22 pathway in IBDR01DK091247 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI REINECKER, HANS-CHRISTIAN · 2013 to 2016
$1.4MNIAID NIH HHS R01 AI113333NIAID NIH HHS U19 AI109725NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R01 DK064869NIDDK NIH HHS R01 DK068181NIDDK NIH HHS R01 DK091247NIDDK NIH HHS U01 DK062432
Abstract
Polymorphisms in
Indexed as
Adherens JunctionsADP-Ribosylation Factor 6ADP-Ribosylation FactorsAnimalsCaco-2 CellsGuanine Nucleotide Exchange FactorsHEK293 CellsHumansImmunoprecipitationInflammatory Bowel DiseasesIntestinal MucosaMiceMice, Mutant StrainsPhosphoproteinsPolymorphism, GeneticProteolysisADP-Ribosylation Factor 6ADP-Ribosylation FactorsAIRIM protein, humanARF6 protein, humanArf6 protein, mousecytohesin-1Guanine Nucleotide Exchange FactorsPhosphoproteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.