ArticleEMBO reports2018
Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance.
Open access · bronzeAbstract read
In one paragraph
Article in EMBO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
6.8field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 115 citations in OpenAlex.
- The role and mechanism of UPRmt in adipocytes.Adipocyte · 2026Review
- Pharmacological inhibition of CLPP stabilizes LETMD1 to boost thermogenesis and alleviate obesity.Adipocyte · 2026Article
- Mitochondrial quality control in health and disease: mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- A Non-Canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver.Aging cell · 2026Article
- Bioinformatic Analyses of the Ataxin-2 Family Since Algae Emphasize Its Small Isoforms, Large Chimerisms, and the Importance of Human Exon 1B as Target of Therapies to Prevent Neurodegeneration.International journal of molecular sciences · 2026Article
- Acetylation of the Mitochondrial Chaperone GRP75 Governs ER-Mitochondrial Calcium Homeostasis and Hepatocyte Insulin Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The effect of enhanced glycolysis on cardiac aging.GeroScience · 2025Article
- Exploring Cirrhosis: Insights into Advances in Therapeutic Strategies.International journal of molecular sciences · 2025Review
- Reduced liver mitochondrial energy metabolism impairs food intake regulation following gastric preloads and fasting.Molecular metabolism · 2025Article
- Mitochondrial Maintenance in Skeletal Muscle.Cold Spring Harbor perspectives in biology · 2025Review
- Mipep deficiency in adipocytes impairs mitochondrial protein maturation and leads to systemic inflammation and metabolic dysfunctions.Scientific reports · 2025Article
- Acute treadmill exercise induces mitochondrial unfolded protein response in skeletal muscle of male rats.Biochimica et biophysica acta. Bioenergetics · 2025Article
- Sexually dimorphic metabolic effects of a high fat diet on knee osteoarthritis in mice.Biology of sex differences · 2024Article
- Aging exacerbates oxidative stress and liver fibrosis in an animal model of Down Syndrome.Aging · 2024Article
- Review
- Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High-Fat, High-Fructose, High-Cholesterol Diet Mouse Model.International journal of molecular sciences · 2024Article
- CLPP-Null Eukaryotes with Excess Heme Biosynthesis Show Reduced L-arginine Levels, Probably via CLPX-Mediated OAT Activation.Biomolecules · 2024Article
- Beneficial Effects of Low-Grade Mitochondrial Stress on Metabolic Diseases and Aging.Yonsei medical journal · 2024Review
- (+)-Lipoic acid reduces mitochondrial unfolded protein response and attenuates oxidative stress and aging in an in vitro model of non-alcoholic fatty liver disease.Journal of translational medicine · 2024Article
- The Emerging Importance of Mitochondria in White Adipocytes: Neither Last nor Least.Endocrinology and metabolism (Seoul, Korea) · 2023Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Shylesh BhaskaranAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Gavin PharaohAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Rojina RanjitAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Ashley MurphyAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Satoshi MatsuzakiAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Binoj C NairThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Brittany ForbesAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Suzana GispertExperimental Neurology, Goethe University Medical School, Frankfurt am Main, Germany.
Georg AuburgerExperimental Neurology, Goethe University Medical School, Frankfurt am Main, Germany.
Kenneth M HumphriesAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Michael KinterAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Timothy M GriffinAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Sathyaseelan S DeepaAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA deepa-sathyaseelan@ouhsc.edu.ORCID 0000-0002-3669-4820
Oklahoma Medical Research Foundation · USGoethe University Frankfurt · DEThe University of Texas MD Anderson Cancer Center · US
Funding
Proteomics CoreP20GM103447 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI DARRIN R. AKINS · 2012 to 2026
$60.2M Understanding connective tissue development and disease with PDGFR-driven..... P20GM103636 · NIGMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI THOMPSON, LINDA F · 2013 to 2023
$26.9MGEROSCIENCE TRAINING PROGRAM IN OKLAHOMAT32AG052363 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Benjamin Francis Miller, William Edmund Sonntag · 2017 to 2026
$3.6MNIA NIH HHS T32 AG052363NIGMS NIH HHS P20 GM103447NIGMS NIH HHS P20 GM103636
Abstract
Caseinolytic peptidase P (ClpP) is a mammalian quality control protease that is proposed to play an important role in the initiation of the mitochondrial unfolded protein response (UPR
Indexed as
Adipose Tissue, WhiteAnimalsDiet, High-FatEndopeptidase ClpEnergy MetabolismFatty LiverInsulin ResistanceMiceMice, KnockoutMitochondriaObesityUnfolded Protein ResponseCLPP protein, mouseEndopeptidase Clpadipose tissuecaseinolytic peptidase Pinsulin sensitivitymitochondriaobesity
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.