Evidence map›Paper›PMID 29420222›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Human Papillomavirus DNA Methylation as a Biomarker for Cervical Precancer: Consistency across 12 Genotypes and Potential Impact on Management of HPV-Positive Women.

Megan A Clarke, Ana Gradissimo, Mark Schiffman, Jessica Lam, Christopher C Sollecito, Barbara Fetterman, Thomas Lorey, Nancy Poitras, Tina R Raine-Bennett, Philip E Castle and 2 more

Open access · greenAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 3 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. How to evaluate and select cervical screening and triage tests in vaccinated populations.Journal of the National Cancer Institute. Monographs · 2026
    Article
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  13. Advances in cervical cancer: current insights and future directions.Cancer communications (London, England) · 2025
    Review
  14. Article
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  17. Review
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  20. The Future of Cervical Cancer Screening.International journal of women's health · 2024
    Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Megan A Clarke *Division of Cancer Epidemiology and Genetics, NCI, Rockville, MD, USA. megan.clarke@nih.gov.
Ana Gradissimo *Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York.
Mark SchiffmanDivision of Cancer Epidemiology and Genetics, NCI, Rockville, MD, USA.
Jessica LamDepartment of Pediatrics, Albert Einstein College of Medicine, Bronx, New York.
Christopher C SollecitoDepartment of Pediatrics, Albert Einstein College of Medicine, Bronx, New York.
Barbara FettermanRegional Laboratory, The Permanente Medical Group, Oakland, California.
Thomas LoreyRegional Laboratory, The Permanente Medical Group, Oakland, California.
Nancy PoitrasRegional Laboratory, The Permanente Medical Group, Oakland, California.
Tina R Raine-BennettKaiser Permanente Division of Research, Oakland, California.
Philip E CastleDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York.
Nicolas Wentzensen *Division of Cancer Epidemiology and Genetics, NCI, Rockville, MD, USA.
Robert D Burk *Departments of Epidemiology and Population Health, Microbiology and Immunology, and Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, New York.
Albert Einstein College of Medicine · US

Funding

Human Papillomavirus (HPV) Natural History, Genomics and Risk AssessmentZIACP010206 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SCHIFFMAN, MARK · 2010 to 2025
$17.1M
PERSISTENT HUMAN PAPILLOMAVIRUS IN WOMEN AT RISK FOR CERVIX CANCERU01CA078527 · NCI · YESHIVA UNIVERSITY · PI BURK, ROBERT D · 2003 to 2018
$8.6M
Intramural NIH HHS Z99 CA999999NCI NIH HHS U01 CA078527
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA MethylationDNA, ViralAdultAgedBiomarkers, TumorCase-Control StudiesComputational BiologyCpG IslandsFemaleGenotypeHumansMiddle AgedPapillomaviridaePapillomavirus InfectionsPrecancerous ConditionsROC CurveBiomarkers, TumorDNA, Viral

Identifiers

PMID29420222
PMCPMC5932258
OpenAlexW2789286069

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.