Evidence map›Paper›PMID 29420216›Full record

ArticleJournal of the American Heart Association2018

Myocardial Scar Delineation Using Diffusion Tensor Magnetic Resonance Tractography.

Choukri Mekkaoui, Marcel P Jackowski, William J Kostis, Christian T Stoeck, Aravinda Thiagalingam, Timothy G Reese, Vivek Y Reddy, Jeremy N Ruskin, Sebastian Kozerke, David E Sosnovik

Open access · goldAbstract readComparative Study
In one paragraph

Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 61 citations in OpenAlex.

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  7. Cardiac structure discontinuities revealed by ex-vivo microstructural characterization. A focus on the basal inferoseptal left ventricle region.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
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  9. The relationship between myocardial microstructure and strain in chronic infarction using cardiovascular magnetic resonance diffusion tensor imaging and feature tracking.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
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  16. Cardiovascular magnetic resonance imaging of functional and microstructural changes of the heart in a longitudinal pig model of acute to chronic myocardial infarction.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 4 countries.

Choukri MekkaouiDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Boston, MA cmekkaoui@mgh.harvard.edu.
Marcel P JackowskiDepartment of Computer Science, Institute of Mathematics and Statistics, University of São Paulo, Brazil.
William J KostisDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Boston, MA.
Christian T StoeckInstitute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.
Aravinda ThiagalingamCardiology Department, Westmead Hospital, Westmead, New South Wales, Australia.
Timothy G ReeseDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Boston, MA.
Vivek Y ReddyCardiac Arrhythmia Service, Icahn School of Medicine at Mount Sinai, New York, NY.
Jeremy N RuskinCardiac Arrhythmia Service, Department of Medicine, Massachusetts General Hospital Harvard Medical School, Boston, MA.
Sebastian KozerkeInstitute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.
David E SosnovikDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Boston, MA.
Massachusetts General Hospital · USAthinoula A. Martinos Center for Biomedical Imaging · USETH Zurich · CHHarvard University · USIcahn School of Medicine at Mount Sinai · USInstitute for Biomedical Engineering · CHRutgers, The State University of New Jersey · USUniversidade de São Paulo · BRWestmead Hospital · AU

Funding

ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGINGP41RR014075 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 1999 to 2011
$16.4M
Cardiac MRI-Tractography In Vivo: Integrated Imaging of Structure and FunctionR01HL112831 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SOSNOVIK, DAVID E · 2013 to 2016
$3.0M
Molecular and Microstructural Imaging of Cardiomyocyte Apoptosis and AutophagyR01HL093038 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SOSNOVIK, DAVID E · 2008 to 2012
$2.2M
Free-Breathing Diffusion Tensor MRI in Patients Following Myocardial InfarctionR01HL131635 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MEKKAOUI, CHOUKRI · 2016 to 2020
$2.1M
Tracking Cardiac Remodeling in Humans Using In Vivo Diffusion Tensor MRIR56HL125590 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MEKKAOUI, CHOUKRI · 2015 to 2015
$435k
NCRR NIH HHS P41 RR014075NHLBI NIH HHS R01 HL093038NHLBI NIH HHS R01 HL112831NHLBI NIH HHS R01 HL131635NHLBI NIH HHS R56 HL125590
6 · The paper itself

Abstract

backgroundLate gadolinium enhancement (LGE) is the current standard for myocardial scar delineation. In this study, we introduce the tractographic propagation angle (PA), a metric of myofiber curvature (degrees/unit distance) derived from diffusion tensor imaging (DTI), and compare its use to LGE and invasive scar assessment by endocardial voltage mapping. METHODS AND

resultsDTI was performed on 7 healthy human volunteers, 5 patients with myocardial infarction, 6 normal mice, and 7 mice with myocardial infarction. LGE to delineate the infarct and border zones was performed with a 2-dimensional inversion recovery gradient-echo sequence. Ex vivo DTI was performed on 5 normal human and 5 normal sheep hearts. Endocardial electroanatomic mapping and subsequent ex vivo DTI was performed on 5 infarcted sheep hearts. PA in the normal human hearts varied smoothly and was generally <4. The mean PA in the infarct zone was significantly elevated (10.34±1.02 versus 4.05±0.45,

conclusionsWe found a strong correlation between infarct size by PA and LGE in both mice and humans. There was also an inverse relationship between PA values and endocardial voltage. The use of PA may enable myocardial scar delineation and characterization of arrhythmogenic substrate without the need for exogenous contrast agents.

Indexed as

Diffusion Tensor ImagingAction PotentialsAnimalsCase-Control StudiesCicatrixDisease Models, AnimalEndocardiumFemaleHumansMaleMice, Inbred C57BLMyocardial InfarctionMyocardiumPredictive Value of TestsSheep, Domesticdiffusion‐weighted imagingmagnetic resonance imagingmyocardial delayed enhancementmyocardial infarctiontractographyventricular arrhythmia

Identifiers

PMID29420216
PMCPMC5850260
OpenAlexW2793285350

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.