Evidence map›Paper›PMID 29420124›Full record

ArticleOrganogenesis2018

Embryonic skin development and repair.

Michael S Hu, Mimi R Borrelli, Wan Xing Hong, Samir Malhotra, Alexander T M Cheung, Ryan C Ransom, Robert C Rennert, Shane D Morrison, H Peter Lorenz, Michael T Longaker

Open access · bronzeAbstract read
In one paragraph

Article in Organogenesis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 92 citations in OpenAlex.

  1. Article
  2. Microorganisms · 2026
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  12. Human stem cells with in vivo high plasticity generated by cell-cell communication.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Michael S Hua Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery , Division of Plastic Surgery, Stanford University School of Medicine , Stanford , California.
Mimi R Borrellia Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery , Division of Plastic Surgery, Stanford University School of Medicine , Stanford , California.
Wan Xing Honga Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery , Division of Plastic Surgery, Stanford University School of Medicine , Stanford , California.
Samir Malhotraa Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery , Division of Plastic Surgery, Stanford University School of Medicine , Stanford , California.
Alexander T M Cheunga Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery , Division of Plastic Surgery, Stanford University School of Medicine , Stanford , California.
Ryan C Ransoma Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery , Division of Plastic Surgery, Stanford University School of Medicine , Stanford , California.
Robert C Rennerta Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery , Division of Plastic Surgery, Stanford University School of Medicine , Stanford , California.
Shane D Morrisona Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery , Division of Plastic Surgery, Stanford University School of Medicine , Stanford , California.
H Peter Lorenza Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery , Division of Plastic Surgery, Stanford University School of Medicine , Stanford , California.
Michael T Longakera Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery , Division of Plastic Surgery, Stanford University School of Medicine , Stanford , California.
Stanford University · US

Funding

Skin Regeneration: Cellular & Molecular MechanismsR01GM087609 · NIGMS · STANFORD UNIVERSITY · PI LORENZ, HERMANN PETER · 2008 to 2012
$1.6M
Fibroblast lineage mechanisms of scarless skin healingR01GM116892 · NIGMS · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T, LORENZ, HERMANN PETER · 2017 to 2020
$1.2M
NIGMS NIH HHS R01 GM087609NIGMS NIH HHS R01 GM116892
6 · The paper itself

Abstract

Fetal cutaneous wounds have the unique ability to completely regenerate wounded skin and heal without scarring. However, adult cutaneous wounds heal via a fibroproliferative response which results in the formation of a scar. Understanding the mechanism(s) of scarless wound healing leads to enormous clinical potential in facilitating an environment conducive to scarless healing in adult cutaneous wounds. This article reviews the embryonic development of the skin and outlines the structural and functional differences in adult and fetal wound healing phenotypes. A review of current developments made towards applying this clinical knowledge to promote scarless healing in adult wounds is addressed.

Indexed as

Wound HealingAnimalsHumansModels, BiologicalRegenerationRegenerative MedicineSkinTissue Engineeringcutaneousembryogenesisfetal wound healingregenerationscarlessscarringwound healing

Identifiers

PMID29420124
PMCPMC6150059
OpenAlexW2791876068

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.