Evidence map›Paper›PMID 29420119›Full record

ArticleHuman vaccines & immunotherapeutics2018

Cross-protection induced by VA-MENGOC-BC® vaccine.

Rolando Felipe Ochoa-Azze

Abstract readComment
In one paragraph

Article in Human vaccines & immunotherapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
  2. Article
  3. Harnessing Nanocarriers to Advance Vaccine Development.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Immune responses toFrontiers in immunology · 2023
    Review
  8. Preventing invasive meningococcal disease in early infancy.Human vaccines & immunotherapeutics · 2022
    Review
  9. Article
  10. Recent Progress Towards a Gonococcal Vaccine.Frontiers in cellular and infection microbiology · 2022
    Review
  11. Review
  12. Article
  13. Review
  14. The Serogroup B Meningococcal Vaccine Bexsero Elicits Antibodies to Neisseria gonorrhoeae.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
    Article
  15. A meningococcal B vaccine induces cross-protection against gonorrhea.Clinical and experimental vaccine research · 2019
    Article
  16. Cross-reactivity with Brazilian strains ofTherapeutic advances in vaccines and immunotherapy · 2019
    Article
  17. Author reply to VA-MENGOC-BC cross-protection (2018HV0022).Human vaccines & immunotherapeutics · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Rolando Felipe Ochoa-Azzea Department of Immunology , Institute of Basic and Preclinical Sciences, University of Medical Sciences, Senior Researcher at the Finlay Institute of Vaccines , Havana , Cuba.ORCID 0000-0002-8008-2944

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

I would like to comment on the article "Commentary: Impact of meningococcal group B OMV vaccines, beyond their brief", DOI: 10.1080/21645515.2017.1381810. The author states that meningococcal group B OMVs vaccines -such as VA-MENGOC-BC®- may induce moderate protection against Neisseria gonorrhoeae. I agree. However, the author states that "there was no evidence of effectiveness in the younger children." The effectiveness of VA-MENGOC-BC® in heterologous contexts has been higher than 80% in individuals older than 4 years old, but the effectiveness in younger children should not be undervalued; it has usually been higher than 60%, and results markedly higher when evaluated based on mortality rates. There is strong evidence that VA-MENGOC-BC® may induce cross-protection against heterologous N. meningitidis strains and N. gonorrhoeae.

Indexed as

Meningococcal VaccinesChildChild, PreschoolCross ProtectionHumansNeisseria gonorrhoeaeMeningococcal Vaccinesgonorrhoeameningococcal diseaseNeisseria gonorrhoeaeNeisseria meningitidisvaccine

Identifiers

PMID29420119
PMCPMC5989903

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.