Evidence map›Paper›PMID 29420117›Full record

ArticleHuman vaccines & immunotherapeutics2018

Inhibition of IL-10 and TGF-β receptors on dendritic cells enhances activation of effector T-cells to kill cholangiocarcinoma cells.

Chutamas Thepmalee, Aussara Panya, Mutita Junking, Thaweesak Chieochansin, Pa-Thai Yenchitsomanus

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chutamas Thepmaleea Division of Molecular Medicine , Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University , Bangkok , Thailand.
Aussara Panyaa Division of Molecular Medicine , Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University , Bangkok , Thailand.
Mutita Junkinga Division of Molecular Medicine , Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University , Bangkok , Thailand.
Thaweesak Chieochansina Division of Molecular Medicine , Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University , Bangkok , Thailand.
Pa-Thai Yenchitsomanusa Division of Molecular Medicine , Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University , Bangkok , Thailand.
Mahidol University · THSiriraj Hospital · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor escapes host immune responses by producing immunosuppressive cytokines, such as IL-10 and TGF-β, secreted into the tumor microenvironment. These cytokines play important roles in the suppression of dendritic cell (DC) function, leading to decreased immune responses of the effector CD4

Indexed as

Lymphocyte ActivationCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedCholangiocarcinomaCytotoxicity, ImmunologicDendritic CellsHumansInterferon-gammaModels, BiologicalReceptors, Interleukin-10Receptors, Transforming Growth Factor betaInterferon-gammaReceptors, Interleukin-10Receptors, Transforming Growth Factor betacholangiocarcinoma (CCA)dendritic cell (DC)IL-10 receptor (IL-10R)immunosuppressive cytokinesTGF-β receptor (TGF-βR)

Identifiers

PMID29420117
PMCPMC6037468
OpenAlexW2791652972

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.