Evidence map›Paper›PMID 29420021›Full record

ArticleJournal of the American Chemical Society2018

Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB

Marjolein Soethoudt, Sara C Stolze, Matthias V Westphal, Luuk van Stralen, Andrea Martella, Eva J van Rooden, Wolfgang Guba, Zoltan V Varga, Hui Deng, Sander I van Kasteren and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 79 citations in OpenAlex.

  1. Chemical Probes for Investigating the Endocannabinoid System.Current topics in behavioral neurosciences · 2026
    Review
  2. Review
  3. Proteome-Wide Profiling of Olaparib Interactors Using a Biotinylated Photoaffinity Probe.Chembiochem : a European journal of chemical biology · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Rational Design, Synthesis, and Evaluation of Fluorescent CBPharmaceuticals (Basel, Switzerland) · 2023
    Review
  8. Journal of medicinal chemistry · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. [Activation of cannabinoid receptor 2 alleviates acute lung injury in rats with lipopolysaccharide-induced sepsis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Article
  16. Chemical Probes and Activity-Based Protein Profiling for Cancer Research.International journal of molecular sciences · 2022
    Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 3 countries.

Marjolein SoethoudtORCID 0000-0001-9220-3742
Sara C Stolze
Matthias V WestphalLaboratorium für Organische Chemie , Eidgenössische Technische Hochschule Zürich , Vladimir-Prelog-Weg 3 , Zürich 8093 , Switzerland.
Luuk van StralenDepartment of Rheumatology , Leiden University Medical Center , Albinusdreef 2 , Leiden 2333 ZA , The Netherlands.
Andrea Martella
Eva J van Rooden
Wolfgang GubaRoche Innovation Center Basel , F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124 , Basel 4070 , Switzerland.
Zoltan V VargaLaboratory of Cardiovascular Physiology and Tissue Injury , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , 5625 Fishers Lane , Rockville , Maryland 20852 , United States.
Sander I van KasterenORCID 0000-0003-3733-818X
Uwe GretherRoche Innovation Center Basel , F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124 , Basel 4070 , Switzerland.
Adriaan P IJzermanORCID 0000-0002-1182-2259
Pal PacherLaboratory of Cardiovascular Physiology and Tissue Injury , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , 5625 Fishers Lane , Rockville , Maryland 20852 , United States.
Erick M CarreiraLaboratorium für Organische Chemie , Eidgenössische Technische Hochschule Zürich , Vladimir-Prelog-Weg 3 , Zürich 8093 , Switzerland.
Herman S Overkleeft
Andreea Ioan-FacsinayDepartment of Rheumatology , Leiden University Medical Center , Albinusdreef 2 , Leiden 2333 ZA , The Netherlands.
Laura H Heitman
Mario van der Stelt
Leiden University · NLETH Zurich · CHLeiden University Medical Center · NLNational Institutes of Health · USRoche (Switzerland) · CH

Funding

Mechanism of oxidative/nitrosative stress and inflammation-induced tissue injuryZIAAA000375 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI PACHER, PAL · 2009 to 2025
$27.8M
6 · The paper itself

Abstract

Chemical tools and methods that report on G protein-coupled receptor (GPCR) expression levels and receptor occupancy by small molecules are highly desirable. We report the development of LEI121 as a photoreactive probe to study the type 2 cannabinoid receptor (CB

Indexed as

AlkynesHL-60 CellsHumansLigandsMolecular StructureMorpholinesPhotoaffinity LabelsPyridinesReceptor, Cannabinoid, CB2AlkynesLEI121LigandsMorpholinesPhotoaffinity LabelsPyridinesReceptor, Cannabinoid, CB2

Identifiers

PMID29420021
PMCPMC5958339
OpenAlexW2786911310

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.