Evidence map›Paper›PMID 29419749›Full record

ArticleInternational journal of molecular sciences2018

Deficiency of Invariant Natural Killer T Cells Does Not Protect Against Obesity but Exacerbates Atherosclerosis in Ldlr

Savitha Subramanian, Leela Goodspeed, Shari Wang, Yilei Ding, Kevin D O'Brien, Godfrey S Getz, Alan Chait, Catherine A Reardon

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Savitha SubramanianDiabetes Obesity Center for Excellence, Division of Metabolism, Endocrinology and Nutrition, University of Washington, 850 Republican Street Box 35805, Seattle, WA 98109, USA. ssubrama@u.washington.edu.
Leela GoodspeedDiabetes Obesity Center for Excellence, Division of Metabolism, Endocrinology and Nutrition, University of Washington, 850 Republican Street Box 35805, Seattle, WA 98109, USA. leelag@uw.edu.
Shari WangDiabetes Obesity Center for Excellence, Division of Metabolism, Endocrinology and Nutrition, University of Washington, 850 Republican Street Box 35805, Seattle, WA 98109, USA. sawang@uw.edu.
Yilei DingDiabetes Obesity Center for Excellence, Division of Metabolism, Endocrinology and Nutrition, University of Washington, 850 Republican Street Box 35805, Seattle, WA 98109, USA. yilei@uw.edu.
Kevin D O'BrienDivision of Cardiology, University of Washington, Seattle, WA 98195, USA. cardiac@uw.edu.
Godfrey S GetzDepartment of Pathology, University of Chicago, Chicago, IL 60637, USA. getz@bsd.uchicago.edu.
Alan ChaitDiabetes Obesity Center for Excellence, Division of Metabolism, Endocrinology and Nutrition, University of Washington, 850 Republican Street Box 35805, Seattle, WA 98109, USA. achait@u.washington.edu.ORCID 0000-0002-5903-2205
Catherine A ReardonDepartment of Pathology, University of Chicago, Chicago, IL 60637, USA. reardon@uchicago.edu.
University of Washington · USUniversity of Chicago · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI Ellen A Schur · 1986 to 2026
$30.4M
Role of Serum Amyloid A in Diabetic Vascular DiseaseP01HL092969 · NHLBI · UNIVERSITY OF WASHINGTON · PI VAISAR, TOMAS · 2008 to 2019
$23.5M
NKT cells in lipoprotein Metabolism and atherosclerosisR01HL088420 · NHLBI · UNIVERSITY OF CHICAGO · PI GETZ, GODFREY SHALOM · 2008 to 2011
$1.5M
FREE FATTY ACID INHIBITORS IN GLOBAL MYOCARDIAL ISCHEMIAF32HL009352 · NHLBI · DUKE UNIVERSITY · PI HENDRICKSON, STEVEN C · 1995 to 1995
–
NHLBI NIH HHS F32 HL009352NHLBI NIH HHS P01 HL092969NHLBI NIH HHS R01 HL088420NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK035816
6 · The paper itself

Abstract

Obesity is a chronic inflammatory state characterized by altered levels of adipose tissue immune cell populations. Natural killer T (NKT) cells are CD1d restricted lymphocyte subsets that recognize lipid antigens whose level decreases in obese adipose tissue. However, studies in mice with deficiency or increased levels of NKT cells have yielded contradictory results, so the exact role of these cells in obesity and adipose tissue inflammation is not yet established. We previously showed that

Indexed as

Adipose TissueAnimalsAortaAtherosclerosisBody WeightDietDisease Models, AnimalDisease ProgressionEnergy MetabolismFatty LiverMaleMiceMice, KnockoutNatural Killer T-CellsObesityPanniculitisReceptors, LDLadipose tissueatherosclerosisinflammationnatural killer T cells

Identifiers

PMID29419749
PMCPMC5855732
OpenAlexW2789697043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.