Evidence map›Paper›PMID 29418019›Full record

ReviewMovement disorders : official journal of the Movement Disorder Society2018

New Developments in Genetic rat models of Parkinson's Disease.

Rose B Creed, Matthew S Goldberg

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Movement disorders : official journal of the Movement Disorder Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.

  1. A Systematic Review of Oropharyngeal Dysphagia Models in Rodents.International journal of environmental research and public health · 2021
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Modeling of Parkinson's Disease in Different Models.CNS & neurological disorders drug targets · 2025
    Review
  11. Mass spectrometry-based proteomics for biomarker discovery in theNeuroprotection (Chichester, England) · 2024
    Review
  12. Review
  13. Liquid-liquid phase separation and conformational strains ofFrontiers in molecular neuroscience · 2024
    Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Frontiers in neuroscience · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rose B CreedCenter for Neurodegeneration and Experimental Therapeutics, Department of Neurology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Matthew S GoldbergCenter for Neurodegeneration and Experimental Therapeutics, Department of Neurology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
University of Alabama at Birmingham · US

Funding

Mechanisms of age-dependent nigral neuron loss in PINK1 knockout ratsR01NS082565 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI GOLDBERG, MATTHEW S · 2014 to 2016
$1.1M
Mechanisms of protection against age-dependent nigral neuron loss in DJ-1 KO ratsR21NS082888 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI GOLDBERG, MATTHEW S · 2014 to 2015
$422k
NINDS NIH HHS R01 NS082565NINDS NIH HHS R21 NS082888
6 · The paper itself

Abstract

Preclinical research on Parkinson's disease has relied heavily on mouse and rat animal models. Initially, PD animal models were generated primarily by chemical neurotoxins that induce acute loss of dopaminergic neurons in the substantia nigra. On the discovery of genetic mutations causally linked to PD, mice were used more than rats to generate laboratory animals bearing PD-linked mutations because mutagenesis was more difficult in rats. Recent advances in technology for mammalian genome engineering and optimization of viral expression vectors have increased the use of genetic rat models of PD. Emerging research tools include "knockout" rats with disruption of genes in which mutations have been causally linked to PD, including LRRK2, α-synuclein, Parkin, PINK1, and DJ-1. Rats have also been increasingly used for transgenic and viral-mediated overexpression of genes relevant to PD, particularly α-synuclein. It may not be realistic to obtain a single animal model that completely reproduces every feature of a human disease as complex as PD. Nevertheless, compared with mice with the same mutations, many genetic rat animal models of PD better reproduce key aspects of PD including progressive loss of dopaminergic neurons in the substantia nigra, locomotor behavior deficits, and age-dependent formation of abnormal α-synuclein protein aggregates. Here we briefly review new developments in genetic rat models of PD that may have greater potential for identifying underlying mechanisms, for discovering novel therapeutic targets, and for developing greatly needed treatments to slow or halt disease progression. © 2018 International Parkinson and Movement Disorder Society.

Indexed as

Disease Models, Animalalpha-SynucleinAnimalsHumansLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MutationParkinson DiseaseProtein KinasesPTEN-Induced Putative KinaseRatsRats, TransgenicUbiquitin-Protein Ligasesalpha-SynucleinLeucine-Rich Repeat Serine-Threonine Protein Kinase-2parkin proteinProtein KinasesPTEN-Induced Putative KinaseUbiquitin-Protein LigasesDJ-1knockoutLRRK2modelneurotoxinParkin PINK1Parkinson's diseaseratsynucleintransgenicviral

Identifiers

PMID29418019
PMCPMC5992003
OpenAlexW2791669033

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.