Evidence map›Paper›PMID 29418006›Full record

ArticlePhotochemistry and photobiology2018

Light-based methods for whole blood bacterial inactivation enabled by a recirculating flow system.

Gwangseong Kim, Mahsa Karbaschi, Marcus Cooke, Angelo Gaitas

Open access · greenAbstract read
In one paragraph

Article in Photochemistry and photobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Gwangseong KimKytaro, Inc., Miami, FL.
Mahsa KarbaschiOxidative Stress Group, Department of Environmental Health Sciences, Florida International University, Miami, FL.
Marcus CookeOxidative Stress Group, Department of Environmental Health Sciences, Florida International University, Miami, FL.
Angelo GaitasKytaro, Inc., Miami, FL.
Florida International University · USKytaro (United States) · US

Funding

A research and drug development tool for the real time in vitro study of single cR44GM084520 · NIGMS · KYTARO, INC. · PI GAITAS, ANGELO · 2013 to 2015
$1.3M
NIGMS NIH HHS R44 GM084520
6 · The paper itself

Abstract

Light of certain wavelengths can be used to inactivate pathogens. Whole blood is opaque; thus, the penetration of light is reduced. Here, we overcame this limitation using a thin transparent tube that is illuminated from all angles. Three light-based techniques were evaluated: photodynamic therapy (PDT) using a 660-nm light and antibody-photosensitizer conjugates, ultraviolet, and violet light. We observed a reduction of 55-71% of Staphylococcus aureus after 5 h of exposure (starting concentration 10

Indexed as

Blood Bactericidal ActivityLightAnimalsBlood Cell CountColony Count, MicrobialComet AssayImmunoconjugatesMacaca fascicularisMethicillin-Resistant Staphylococcus aureusPhotochemotherapyPhotosensitizing AgentsProof of Concept StudyPyrimidine DimersReactive Oxygen SpeciesStaphylococcus aureusImmunoconjugatesPhotosensitizing AgentsPyrimidine DimersReactive Oxygen Species

Identifiers

PMID29418006
PMCPMC6136252
OpenAlexW2792970995

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.