ArticlePharmacology research & perspectives2018
Improving the assessment of adverse drug reactions using the Naranjo Algorithm in daily practice: The Japan Adverse Drug Events Study.
Article in Pharmacology research & perspectives, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Serious Adverse Events: A Replicability and Validation Study of Naranjo Causality Assessment Tool in a Canadian Clinical Setting.Journal of evaluation in clinical practice · 2025Article
- Clinical Presentations and Characteristics of NSAIDs Hypersensitivity in a Tertiary Care Hospital in Indonesia: A Case Series.International medical case reports journal · 2025Article
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- Clinical Predictors of 3-Months Isoniazid Rifapentine (3HP) - Related Adverse Drug Reactions (ADR) During Tuberculosis Preventive Therapy. (PAnDoRA-3HP study): An Observational Study Protocol.medRxiv : the preprint server for health sciences · 2024Article
- Polymyxin B-induced Bartter syndrome.BMJ case reports · 2024Article
- New Onset and Exacerbation of Autoimmune Bullous Dermatosis Following COVID-19 Vaccination: A Systematic Review.Vaccines · 2024Review
- Safety evaluation of a buffer used in the lyophilization of canine platelets: type I hypersensitivity reaction in dogs caused by bovine serum albumin.Frontiers in veterinary science · 2024Article
- The evaluation of adverse drug reactions in Saudi Arabia: A retrospective observational study.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
- ADR in Journals: Are They Translated into Regulatory Frameworks?Current drug safety · 2022Article
- Statin-Induced Thrombocytopenia in a Young Female: A Case Report and Literature Review.Cureus · 2021Article
- Vasculitis associated with the use of an intrauterine device: A case report.Experimental and therapeutic medicine · 2021Article
- Sumatriptan dose increase-induced acute angle closure glaucoma in chronic migraine sufferer.BMJ case reports · 2021Article
- Atorvastatin-Induced Refractory Thrombocytopenia.Cureus · 2021Article
- Drug-induced anaphylaxis in the emergency department: A prospective observational study.Northern clinics of Istanbul · 2021Article
- Utilization of the Naranjo scale to evaluate adverse drug reactions at a free-standing children's hospital.PloS one · 2021Article
- Prevalence, Incidence, and Characteristics of Adverse Drug Reactions Among Older Adults Hospitalized at Mbarara Regional Referral Hospital, Uganda: A Prospective Cohort Study.Clinical interventions in aging · 2021Article
- Benzodiazepine-Related Cognitive Impairment or Dementia: A Signal Detection Study Using a Case/Non-Case Approach.Psychiatry investigation · 2020Article
- Improving the assessment of adverse drug reactions using the Naranjo Algorithm in daily practice: The Japan Adverse Drug Events Study.Pharmacology research & perspectives · 2018Article
- American Geriatrics Society-Beers Criteria and adverse drug reactions: a comparative cross-sectional study of Nigerian and South African older inpatients.Clinical interventions in aging · 2018Article
Corrections and comments
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Authors and funding
4 authors.
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Abstract
It is difficult to determine adverse drug reactions (ADRs) in daily complicated clinical practice in which many kinds of drugs are prescribed. We evaluated how well the Naranjo Algorithm (NA) categorized ADRs among suspected ADRs. The Japan Adverse Drug Events (JADE) study was a prospective cohort study of 3459 inpatients. After all suspected ADRs were reported from research assistants, a single physician reviewer independently assigned an NA score to each. After all NA score of suspected ADRs were scored, two physician reviewers discussed and determined ADRs based on the literature. We investigated the sensitivity and specificity of NA and each component to categorize ADRs among suspected ADRs. A total of 1579 suspected ADRs were reported in 962 patients. Physician reviewers determined 997 ADRs. The percentage of ADRs was 94% if the total NA score reached 5. The modified NA consisted of 5 components that showed high classification abilities; its area under the curve (AUC) was 0.92 for categorizing ADRs, the same as the original. When we set the total NA score cut-off value to 5, specificity was 0.95 and sensitivity was 0.59. When we reclassified NA components as binary variables, the specificity increased to 0.98 with a cut-off value of 4 and yielded an AUC of 0.93. In conclusion, we showed that both NA and modified NA could categorize ADRs among suspected ADRs with a high likelihood in daily clinical practice.
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