Evidence map›Paper›PMID 29417728›Full record

ArticleJournal of applied clinical medical physics2018

Comparison of four techniques for spine stereotactic body radiotherapy: Dosimetric and efficiency analysis.

Saif Aljabab, Balamurugan Vellayappan, Eric Vandervoort, Jamie Bahm, Robert Zohr, John Sinclair, Jean-Michel Caudrelier, Janos Szanto, Shawn Malone

Open access · goldAbstract readComparative Study
In one paragraph

Article in Journal of applied clinical medical physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Improved outcomes of cyberknife stereotactic radiosurgery for spinal metastases: a retrospective study of sixty-one cases in one single center.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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  5. Combination of stereotactic radiotherapy and targeted therapy: patterns-of-care survey in German-speaking countries.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Saif AljababRadiation Medicine Program, The Ottawa Hospital Cancer Centre, Ottawa, ON, Canada.
Balamurugan VellayappanDivision of Radiation Oncology, National University Cancer Institute, Singapore.
Eric VandervoortRadiation Medicine Program, The Ottawa Hospital Cancer Centre, Ottawa, ON, Canada.
Jamie BahmRadiation Medicine Program, The Ottawa Hospital Cancer Centre, Ottawa, ON, Canada.
Robert ZohrRadiation Medicine Program, The Ottawa Hospital Cancer Centre, Ottawa, ON, Canada.
John SinclairDivision of Neurosurgery, University of Ottawa, Ottawa, ON, Canada.
Jean-Michel CaudrelierRadiation Medicine Program, The Ottawa Hospital Cancer Centre, Ottawa, ON, Canada.
Janos SzantoRadiation Medicine Program, The Ottawa Hospital Cancer Centre, Ottawa, ON, Canada.
Shawn MaloneRadiation Medicine Program, The Ottawa Hospital Cancer Centre, Ottawa, ON, Canada.
Ottawa Hospital · CAUniversity of Ottawa · CANational University Cancer Institute, Singapore · SGOttawa Hospital Research Institute

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study is to compare the dosimetric differences between four techniques for spine stereotactic body radiotherapy (SBRT): CyberKnife (CK), volumetric modulated arc therapy (VMAT), and helical tomotherapy (HT) with dynamic jaws (HT-D) and fixed jaws (HT-F). MATERIALS/

methodsData from 10 patients were utilized. All patients were planned for 24 Gy in two fractions, with the primary objectives being: (a) restricting the maximum dose to the cord to ≤ 17 Gy and/or cauda equina to ≤ 20 Gy, and (b) to maximize the clinical target volume (CTV) to receive the prescribed dose. Treatment plans were generated by separate dosimetrists and then compared using velocity AI. Parameters of comparison include target volume coverage, conformity index (CI), gradient index (GI), homogeneity index (HI), treatment time (TT) per fraction, and monitor units (MU) per fraction.

resultsPTV D2 and D5 were significantly higher for CK compared to VMAT, HT-F, and HT-D (P < 0.001). The average volume of CTV receiving the prescription dose (CTV D95) was significantly less for VMAT compared to CK, HT-F and HT-D (P = 0.036). CI improved for CK (0.69), HT-F (0.66), and HT-D (0.67) compared to VMAT (0.52) (P = 0.013). CK (41.86) had the largest HI compared to VMAT (26.99), HT-F (20.69), and HT-D (21.17) (P < 0.001). GI was significantly less for CK (3.96) compared to VMAT (6.76) (P = 0.001). Likewise, CK (62.4 min, 14059 MU) had the longest treatment time and MU per fraction compared to VMAT (8.5 min, 9764 MU), HT-F (13 min, 10822 MU), and HT-D (13.5 min, 11418 MU) (P < 0.001).

conclusionBoth CK and HT plans achieved conformal target coverage while respecting cord tolerance. Dose heterogeneity was significantly larger in CK. VMAT required the least treatment time and MU output, but had the least steep GI, CI, and target coverage.

Indexed as

AgedAged, 80 and overFemaleHumansMaleMiddle AgedOrgans at RiskPrognosisRadiometryRadiosurgeryRadiotherapy DosageRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedRetrospective StudiesSpinal Neoplasmsconformity indexcyberknifedosimetric evaluationdynamic wedgesspine SBRTtomotherapyVMAT

Identifiers

PMID29417728
PMCPMC5849852
OpenAlexW2789968037

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.