ArticleCancer science2018
Metastatic ability and the epithelial-mesenchymal transition in induced cancer stem-like hepatoma cells.
Article in Cancer science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Single-cell multi-omics and machine learning for dissecting stemness in cancer.Briefings in bioinformatics · 2025Review
- Exploring the metabolic signaling network of GFPT in cancer.Cell death discovery · 2025Review
- The role of liver cancer stem cells in hepatocellular carcinoma metastasis.Cancer biology & therapy · 2024Review
- Advancements in Understanding the Role of Circular RNA in Osteosarcoma.Molecular biotechnology · 2024Review
- Protein phosphatase 6 promotes stemness of colorectal cancer cells.Cancer science · 2024Article
- Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer.Functional & integrative genomics · 2023Review
- Immune Evasion of Hepatoma Cancer Stem-Like Cells from Natural Killer Cells.Annals of surgical oncology · 2022Article
- Elevated expression of RAB3B plays important roles in chemoresistance and metastatic potential of hepatoma cells.BMC cancer · 2022Article
- CircRNA: A novel potential strategy to treat thyroid cancer (Review).International journal of molecular medicine · 2021Review
- MicroRNA‑8063 targets heterogeneous nuclear ribonucleoprotein AB to inhibit the self‑renewal of colorectal cancer stem cells via the Wnt/β‑catenin pathway.Oncology reports · 2021Article
- circFBXW7 attenuates malignant progression in lung adenocarcinoma by sponging miR-942-5p.Translational lung cancer research · 2021Article
- Exosomal circRNAs: Emerging Players in Tumor Metastasis.Frontiers in cell and developmental biology · 2021Review
- Clinical implications of cancer stem cells in digestive cancers: acquisition of stemness and prognostic impact.Surgery today · 2020Review
- The DNMT1/miR-34a/FOXM1 Axis Contributes to Stemness of Liver Cancer Cells.Journal of oncology · 2020Article
- Functional roles of circular RNAs during epithelial-to-mesenchymal transition.Molecular cancer · 2019Review
- Tobacco smoke induced hepatic cancer stem cell-like properties through IL-33/p38 pathway.Journal of experimental & clinical cancer research : CR · 2019Article
- Impact of high-mobility-group A2 overexpression on epithelial-mesenchymal transition in pancreatic cancer.Cancer management and research · 2019Article
- 4Mu Decreases CD47 Expression on Hepatic Cancer Stem Cells and Primes a Potent Antitumor T Cell Response Induced by Interleukin-12.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Functional Role of Non-Coding RNAs during Epithelial-To-Mesenchymal Transition.Non-coding RNA · 2018Review
- Metastatic ability and the epithelial-mesenchymal transition in induced cancer stem-like hepatoma cells.Cancer science · 2018Article
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer stem cells (CSCs) are thought to play important roles in cancer malignancy. Previously, we successfully induced sphere cancer stem-like cells (CSLCs) from several cell lines and observed the property of chemoresistance. In the present study, we examined the metastatic potential of these induced CSLCs. Sphere cancer stem-like cells were induced from a human hepatoma cell line (SK-HEP-1) in a unique medium containing neural survival factor-1. Splenic injection of cells into immune-deficient mice was used to assess hematogenous liver metastasis. Transcriptomic strand-specific RNA-sequencing analysis, quantitative real-time PCR, and flow cytometry were carried out to examine the expression of epithelial-mesenchymal transition (EMT)-related genes. Splenic injection of CSLCs resulted in a significantly increased frequency of liver metastasis compared to parental cancer cells (P < .05). In CSLCs, a mesenchymal marker, Vimentin, and EMT-promoting transcription factors, Snail and Twist1, were upregulated compared to parental cells. Correspondingly, significant enrichment of the molecular signature of the EMT in CSLCs relative to parental cancer cells was shown (q < 0.01) by RNA-sequencing analysis. This analysis also revealed differential expression of CD44 isoforms between CSLCs and parental cancer cells. Increasing CD44 isoforms containing an extra exon were observed, and the standard CD44 isoform decreased in CSLCs compared to parental cells. Interestingly, another CD44 variant isoform encoding a short cytoplasmic tail was also upregulated in CSLCs (11.7-fold). Our induced CSLCs possess an increased liver metastatic potential in which promotion of the EMT and upregulation of CD44 variant isoforms, especially short-tail, were observed.
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