Evidence map›Paper›PMID 29417495›Full record

ArticleDiabetes therapy : research, treatment and education of diabetes and related disorders2018

Effectiveness and Safety of a Novel Care Model for the Management of Type 2 Diabetes at 1 Year: An Open-Label, Non-Randomized, Controlled Study.

Sarah J Hallberg, Amy L McKenzie, Paul T Williams, Nasir H Bhanpuri, Anne L Peters, Wayne W Campbell, Tamara L Hazbun, Brittanie M Volk, James P McCarter, Stephen D Phinney and 1 more

Erratum issued 2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 209 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
209citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02519309 nacompletednot on this map

Dietary Intervention in Type-2 Diabetics and Pre-Diabetics Emphasizing Personalized Carbohydrate Intake

TypeinterventionalSponsorVirta HealthRan2015 to 2021Enrolled465ConditionsDiabetes Mellitus, Type 2, Pre-diabetes, Metabolic SyndromeArmsVirta Program
NCT04130724 completednot on this mapstarted 2019, after this paper: background citation

Characterization of a Portable Solid-State Breath Acetone Testing Device for Real-Time Ketosis Status and Comparison to Blood Ketone Testing

TypeobservationalSponsorReadout, Inc.Ran2019 to 2019Enrolled21ConditionsKetogenic Dieting, KetosisArmsBlood ketone testing, Breath ketone testing
3 · Its place in the literature

Who cites it

209 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Relationship between Aging and Ketogenic Diet: A Bibliometric Analysis (1995-2025)Endocrine, metabolic & immune disorders drug targets · 2026
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149 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Sarah J HallbergMedically Supervised Weight Loss, Indiana University Health Arnett, Lafayette, IN, USA.
Amy L McKenzieVirta Health, San Francisco, CA, USA. amy@virtahealth.com.
Paul T WilliamsIndependent Consultant, Lafayette, CA, USA.
Nasir H BhanpuriVirta Health, San Francisco, CA, USA.
Anne L PetersKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Wayne W CampbellDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.
Tamara L HazbunMedically Supervised Weight Loss, Indiana University Health Arnett, Lafayette, IN, USA.
Brittanie M VolkVirta Health, San Francisco, CA, USA.
James P McCarterVirta Health, San Francisco, CA, USA.
Stephen D PhinneyVirta Health, San Francisco, CA, USA.
Jeff S VolekVirta Health, San Francisco, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCarbohydrate restriction markedly improves glycemic control in patients with type 2 diabetes (T2D) but necessitates prompt medication changes. Therefore, we assessed the effectiveness and safety of a novel care model providing continuous remote care with medication management based on biometric feedback combined with the metabolic approach of nutritional ketosis for T2D management.

methodsWe conducted an open-label, non-randomized, controlled, before-and-after 1-year study of this continuous care intervention (CCI) and usual care (UC). Primary outcomes were glycosylated hemoglobin (HbA

results349 adults with T2D enrolled: CCI: n = 262 [mean (SD); 54 (8) years, 116.5 (25.9) kg, 40.4 (8.8) kg m

conclusionsThese results demonstrate that a novel metabolic and continuous remote care model can support adults with T2D to safely improve HbA GOV IDENTIFIER: NCT02519309.

fundingVirta Health Corp.

Indexed as

Beta-hydroxybutyrateCarbohydrate restrictionHbA1cKetosisType 2 diabetesWeight loss

Identifiers

PMID29417495
PMCPMC6104272

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.