Evidence map›Paper›PMID 29417414›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2019

Development of an inflammation imaging tracer,

Lihui Wei, Julia Petryk, Chantal Gaudet, Maryam Kamkar, Wei Gan, Yin Duan, Terrence D Ruddy

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. The Theranostic Genome.Nature communications · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Development of NovelBiomolecules · 2020
    Article
  8. Current and novel radiopharmaceuticals for imaging cardiovascular inflammation.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... · 2020
    Review
  9. Diabetic vasculopathy: macro and microvascular injury.Current pathobiology reports · 2020
    Article
  10. Article
  11. Chemokine receptors: Key for molecular imaging of inflammation in atherosclerosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Article
  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lihui WeiNordion Inc., 447 March Road, Ottawa, ON, K2K 1X8, Canada. lihuiwei@yahoo.com.
Julia PetrykDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
Chantal GaudetDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
Maryam KamkarDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
Wei GanDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
Yin DuanDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
Terrence D RuddyDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
University of Ottawa · CANordion (Canada) · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChemokine receptor 5 (CCR5) plays an important role in atherosclerosis. Our objective was to develop a SPECT tracer targeting CCR5 for imaging plaque inflammation by radiolabeling D-Ala-peptide T-amide (DAPTA), a CCR5 antagonist, with

methods1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) conjugated DAPTA (DOTA-DAPTA) was labeled with

resultsDOTA-DAPTA was radiolabeled with

conclusion

Indexed as

AlanineAnimalsAtherosclerosisCD4-Positive T-LymphocytesCell Line, TumorFemaleHeterocyclic Compounds, 1-RingHumansIndium RadioisotopesInflammationMiceMice, Inbred C57BLMice, Knockout, ApoEReceptors, CCR5Tomography, Emission-Computed, Single-Photon1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidAlanineCCR5 protein, humanCCR5 protein, mouseD-Ala-peptide T-amideHeterocyclic Compounds, 1-RingIndium RadioisotopesReceptors, CCR5111In-DOTA-DAPTAApoE−/− miceatherosclerosisautoradiographyCCR5

Identifiers

PMID29417414
OpenAlexW2791719102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.