Evidence map›Paper›PMID 29417057›Full record

ArticleMicrobial cell (Graz, Austria)2017

Fat storage-inducing transmembrane (FIT or FITM) proteins are related to lipid phosphatase/phosphotransferase enzymes.

Matthew Hayes, Vineet Choudhary, Namrata Ojha, John Jh Shin, Gil-Soo Han, George M Carman, Christopher Jr Loewen, William A Prinz, Timothy Levine

Open access · goldAbstract read
In one paragraph

Article in Microbial cell (Graz, Austria), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Potential of a constitutive-UPR and histone deacetylase A-deficientApplied and environmental microbiology · 2025
    Article
  5. Review
  6. Review
  7. Review
  8. The evolving landscape of ER-LD contact sites.Frontiers in cell and developmental biology · 2024
    Review
  9. Concept of lipid droplet biogenesis.European journal of cell biology · 2023
    Review
  10. Review
  11. Review
  12. Review
  13. Lipid Droplet-a New Target in Ischemic Heart Disease.Journal of cardiovascular translational research · 2022
    Review
  14. Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  15. Article
  16. Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  17. Review
  18. The yeastJournal of cell science · 2020
    Article
  19. Protein Quality Control and Lipid Droplet Metabolism.Annual review of cell and developmental biology · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Matthew HayesUniversity College London Institute of Ophthalmology. 11-43 Bath Street, London, EC1V 9EL, UK.
Vineet ChoudharyLaboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Namrata OjhaLaboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
John Jh ShinDepartment of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Gil-Soo HanDepartment of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, New Jersey 08901, USA.
George M CarmanDepartment of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, New Jersey 08901, USA.
Christopher Jr LoewenDepartment of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
William A PrinzLaboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Timothy LevineUniversity College London Institute of Ophthalmology. 11-43 Bath Street, London, EC1V 9EL, UK.
National Institutes of Health · USUniversity of British Columbia · CANational Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

Intracellular Lipid Trafficking and Organelle BiogenesisZIADK060004 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI PRINZ, WILLIAM · 2009 to 2022
$8.5M
Phospholipid metabolism and membrane functionR37GM028140 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI CARMAN, GEORGE M. · 2010 to 2019
$4.0M
PHOSPHOLIPID METABOLSIM AND MEMBRANE FUNCTIONR01GM028140 · NIGMS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI CARMAN, GEORGE M. · 1985 to 2009
$3.2M
Biotechnology and Biological Sciences Research Council BB/M011801/1Biotechnology and Biological Sciences Research Council BB/P003818/1NIGMS NIH HHS R01 GM028140NIGMS NIH HHS R37 GM028140Wellcome Trust
6 · The paper itself

Abstract

Fat storage-inducing transmembrane (FIT or FITM) proteins have been implicated in the partitioning of triacylglycerol to lipid droplets and the budding of lipid droplets from the ER. At the molecular level, the sole relevant interaction is that FITMs directly bind to triacyglycerol and diacylglycerol, but how they function at the molecular level is not known.

Indexed as

endoplasmic reticulum retention motifendoplasmic reticulum stresslipid biosynthesis enzymelipid dropletremote homology searchtype 2 diabetes

Identifiers

PMID29417057
PMCPMC5798408
OpenAlexW2783340780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.