ArticleAmerican journal of cancer research2018
Herniation of crypts in hyperplastic polyp and sessile serrated adenoma: a prospective study.
Article in American journal of cancer research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.
- Endoscopic diagnosis of sessile serrated polyp: A systematic review.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2019Pooled it
- Colorectal sessile serrated lesion with large size or synchronous neoplasm: a prospective study.European journal of gastroenterology & hepatology · 2020Article
- MLH1, BRAF and p53 - searching for significant markers to predict evolution towards adenocarcinoma in colonic sessile serrated lesions.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Presence of colonic crypts in submucosa was previously termed as herniation of crypts, pseudoinvasion, epithelial-misplacement, or inverted hyperplastic-polyp. It is considered as an important criterion for diagnosing sessile serrated adenoma (SSA), which links to a higher risk of synchronous and future colorectal cancers compared with hyperplastic polyp (HP). Here, we aimed to study the frequencies, diagnostic specificity and synchronous neoplasms of herniation of crypts in HP and SSA. We prospectively included all HP and SSA cases and 514 randomly-selected colorectal polyps of normal histology diagnosed from 2013 to 2015 at our institution. We calculated the frequencies of herniation of crypts by histology, sex, age, size, race, location, prior polyp-history and synchronous neoplasms (including colorectal cancers and adenomas). Binary and ordinal (ordered) logistic regression analyses were used to identify potential associations. Among the 2,560 colorectal polyps in the subjects with average-risk of colorectal cancer, the frequencies of herniation of crypts were 1.79% (10/559) in SSA, 0.2% (3/1487) in HP and 0% (0/514) in polypoid normal tissue. The specificity of herniation of crypts for diagnosing serrated polyp (HP and SSA versus normal tissue) was 100% (514/514), but its sensitivity was 0.64% (13/2046), while the specificity of herniation of crypts for diagnosing SSA (versus HP and polypoid normal tissue) was 99.85% (1998/2001) and its sensitivity was 1.79% (10/559). Our multivariate analyses identified an independent association between herniation of crypts and diagnosis of SSA (Odds ratio [OR]=9.37,
Indexed as
Identifiers
29416927PMC5794728W2989941780What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.