Evidence map›Paper›PMID 29416866›Full record

ArticleJournal of materials chemistry. B2015

The evolution of fibrin-specific targeting strategies.

Victoria L Stefanelli, Thomas H Barker

Abstract read
In one paragraph

Article in Journal of materials chemistry. B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Identification of and solution for false D-dimer results.Journal of clinical laboratory analysis · 2020
    Article
  5. Review
  6. What makes D-dimer assays suspicious-heterophilic antibodies?Journal of clinical laboratory analysis · 2019
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Victoria L StefanelliThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA.
Thomas H BarkerThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA.

Funding

Platelet-like particles for augmenting hemostasisR01HL130918 · NHLBI · UNIVERSITY OF VIRGINIA · PI BARKER, THOMAS HARRISON, LAM, WILBUR A · 2016 to 2019
$2.7M
Engineering fibrin polymers for enhanced angiogenesisR01EB011566 · NIBIB · GEORGIA INSTITUTE OF TECHNOLOGY · PI BARKER, THOMAS HARRISON · 2010 to 2013
$1.5M
Augmentation of Hemostasis in Pediatric Cardiopulmonary BypassR21EB019068 · NIBIB · EMORY UNIVERSITY · PI BARKER, THOMAS HARRISON, GUZZETTA, NINA · 2014 to 2015
$450k
Fibrinogen-Triggered Matrix Assembly from Designed Peptide-Polymer ConjugatesR21EB013743 · NIBIB · GEORGIA INSTITUTE OF TECHNOLOGY · PI BARKER, THOMAS HARRISON, LYON, LOUIS ANDREW · 2012 to 2013
$384k
NHLBI NIH HHS R01 HL130918NIBIB NIH HHS R01 EB011566NIBIB NIH HHS R21 EB013743NIBIB NIH HHS R21 EB019068
6 · The paper itself

Abstract

Fibrin-specific targeting capabilities have been highly sought for over 50 years due to their implications for bio-molecule delivery, diagnostics, and regenerative medicine. Yet only recently has our full knowledge of fibrin's complex polymerization dynamics and biological interactions begun to be fully exploited in pursuit of this goal. This highlight will discuss the range of rapidly changing strategies for specifically targeting fibrin over the precursor fibrinogen and the advantages and disadvantages of these approaches for various applications.

Identifiers

PMID29416866
PMCPMC5798253

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.