ArticleOncotarget2018
Clinicopathological features and prognosis of intestinal hepatoid adenocarcinoma: evaluation of a pooled case series.
Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- A Clinical Guidance for the Management of Patients With Hepatoid Adenocarcinoma and A Case Series.Cancer medicine · 2026Review
- Case Report: Metastatic duodenal hepatoid adenocarcinoma: a rare pathology with exceptional response to dual immune checkpoint blockade.Frontiers in oncology · 2026Article
- Intracholecystic Papillary Neoplasm With Associated Invasive Carcinoma, Accompanied by Tumor Thrombi of Hepatoid Adenocarcinoma: A Case Report.Case reports in pathology · 2025Article
- A 47-year-old female with primary hepatoid adenocarcinoma in the pelvic retroperitoneum.Quantitative imaging in medicine and surgery · 2023Article
- Hepatoid adenocarcinoma of the duodenal papilla with hepatic metastases: A case report and literature review.Frontiers in oncology · 2022Article
- Alpha-fetoprotein-producing Colon Carcinoma with Rapidly Increasing Liver Metastases That Resulted in Death: A Case Report.Journal of the anus, rectum and colon · 2021Article
- Incidence and prognostic factors of hepatoid adenocarcinoma: a population-based analysis.Translational cancer research · 2020Article
- Review
- Therapeutic Approaches to Gastric Hepatoid Adenocarcinoma: Current Perspectives.Therapeutics and clinical risk management · 2019Review
- Clinicopathological features and prognosis of AFP-producing colorectal cancer: a single-center analysis of 20 cases.Cancer management and research · 2019Article
- Non-α-fetoprotein-producing adrenal hepatoid adenocarcinoma: A case report and literature review.Medicine · 2018Review
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroudIntestinal hepatoid adenocarcinoma (IHA) is a very rare and unique intestinal malignancy. Due to the lack of case series specifically pertaining to IHA, the clinicopathological features and prognosis of it remain unclear.
resultsOf the 42 patients enrolled in this study, 30 (71.4%) were male. Twenty-one cases (50.0%) were located in the colon. Eight cases (19.0%) had accompanying inflammatory bowel disease (IBD). Elevated serum alpha-fetoprotein (AFP) was detected for most patients (25/33, 84.8%). Twenty-five (59.5%) patients received complete resections. Vascular invasion (22/36, 61.1%), lymph node metastasis (28/36, 77.8%) and distant metastasis (21/42, 50.0%) were common. The 1-year progression-free survival (PFS) and disease-specific survival (DSS) of IHA were 26.9% and 30.6%, respectively. Multivariate analysis showed that only pTNM stage was an independent risk factor for PFS and DSS. PFS and DSS in patients with IHA were significantly lower than those with colorectal adenocarcinoma (CA) and hepatoid adenocarcinoma of the stomach (HAS).
conclusionsIHA most commonly occurred in the colon and accompanied by IBD in several cases. pTNM stage was an independent factor for prognosis. The prognosis of IHA was significantly worse than that of CA and HAS. PATIENTS AND
methodsClinical data of IHA from four patients managed at our institution between January 2010 and December 2016, and 38 cases from research databases prior to 2017 were retrospectively studied.
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