Evidence map›Paper›PMID 29416749›Full record

ArticleOncotarget2018

microRNA-19a protects osteoblasts from dexamethasone via targeting TSC1.

Gang Liu, Feng-Li Chen, Feng Ji, Hao-Dong Fei, Yue Xie, Shou-Guo Wang

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Role of TSC1 in physiology and diseases.Molecular and cellular biochemistry · 2021
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Gang LiuDepartment of Orthopedics, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
Feng-Li ChenClinical Laboratory, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
Feng JiDepartment of Orthopedics, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
Hao-Dong FeiDepartment of Orthopedics, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
Yue XieDepartment of Orthopedics, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
Shou-Guo WangDepartment of Orthopedics, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
Huaian First People’s Hospital · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activation of mTOR complex 1 (mTORC1) could protect human osteoblasts from dexamethasone. Tuberous sclerosis complex 1 (TSC1) is mTORC1 upstream inhibitory protein. We demonstrate here that microRNA-19a ("miR-19a", -3p) targets the 3' untranslated regions of

Indexed as

dexamethasonemicroRNA-19amTOR complex 1 (mTORC1)osteoblaststuberous sclerosis complex 1 (TSC1)

Identifiers

PMID29416749
PMCPMC5788617
OpenAlexW2771079229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.