Evidence map›Paper›PMID 29416614›Full record

ArticleOncotarget2018

Extracellular signal regulated kinase 5 and inflammasome in progression of mesothelioma.

Joyce K Thompson, Anurag Shukla, Alan L Leggett, Phillip B Munson, Jill M Miller, Maximilian B MacPherson, Stacie L Beuschel, Harvey I Pass, Arti Shukla

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. How asbestos and other fibers cause mesothelioma.Translational lung cancer research · 2020
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Impact of ERK5 on the Hallmarks of Cancer.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Joyce K ThompsonDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA.
Anurag ShuklaDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA.
Alan L LeggettDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA.
Phillip B MunsonDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA.
Jill M MillerDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA.
Maximilian B MacPhersonDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA.
Stacie L BeuschelDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA.
Harvey I PassDepartment of Cardiothoracic Surgery, Langone Medical Center, New York University, New York, NY 10012, USA.
Arti ShuklaDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA.
University of Vermont · USNYU Langone Health · US

Funding

Inflammasomes in pathogenesis of mesotheliomaR01ES021110 · NIEHS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SHUKLA, ARTI · 2012 to 2016
$1.7M
INVERTED LASER-SCANNING CONFOCAL MICROSCOPE: LUNG RESEARCHS10RR019246 · NCRR · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TAATJES, DOUGLAS J. · 2004 to 2004
$473k
NCRR NIH HHS S10 RR019246NIEHS NIH HHS R01 ES021110
6 · The paper itself

Abstract

Malignant mesothelioma is an aggressive cancer in desperate need of treatment. We have previously shown that extracellular signaling regulated kinase 5 (ERK5) plays an important role in mesothelioma pathogenesis using ERK5 silenced human mesothelioma cells exhibiting significantly reduced tumor growth in immunocompromised mice. Here, we used a specific ERK 5 inhibitor, XMD8-92 in various

Indexed as

asbestosextracellular signal regulated kinase 5inflammasomemesotheliomaXMD8-92

Identifiers

PMID29416614
PMCPMC5787465
OpenAlexW2773684970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.