Evidence map›Paper›PMID 29416613›Full record

ArticleOncotarget2018

Efficient inhibition of cervical cancer by dual drugs loaded in biodegradable thermosensitive hydrogel composites.

Shan Xu, Xiaobo Du, Gang Feng, Yu Zhang, Jie Li, Binwei Lin, Linglin Yang, Shaozhi Fu, Jingbo Wu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Shan XuDepartment of Oncology, Mianyang Central Hospital, Mianyang 621000, Sichuan Province, China.
Xiaobo DuDepartment of Oncology, Mianyang Central Hospital, Mianyang 621000, Sichuan Province, China.
Gang FengDepartment of Oncology, Mianyang Central Hospital, Mianyang 621000, Sichuan Province, China.
Yu ZhangDepartment of Oncology, Mianyang Central Hospital, Mianyang 621000, Sichuan Province, China.
Jie LiDepartment of Oncology, Mianyang Central Hospital, Mianyang 621000, Sichuan Province, China.
Binwei LinDepartment of Oncology, Mianyang Central Hospital, Mianyang 621000, Sichuan Province, China.
Linglin YangDepartment of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China.
Shaozhi FuDepartment of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China.
Jingbo WuDepartment of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China.
Mianyang Central Hospital · CNAffiliated Hospital of Southwest Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeWe aimed to explore the anti-tumor effect and mechanism of the combination of cisplatin (DDP)-containing thermosensitive hydrogel (PEG-PCL-PEG, or PECE) and paclitaxel (PTX)-loaded MPEG-PCL polymeric micelles called PDMP on human cervical carcinoma (HeLa) cell. In our previous studies, we found that PDMP

resultsCompared with other treatments, PDMP was most effective in prolonging survival time (

conclusionsPDMP is regarded as a promising anti-tumor reactant, when it comes to the treatment of cervical carcinoma.

methodswe used a xenograft cervical cancer model to verify the anti-tumor activity of PDMP and to explore its mechanism of action. Mice were intratumorally administered with NS, PECE, PTX+DDP or PDMP. After two days of treatment, three mice per group were sacrificed and tumor tissue was harvested. Levels of histone H2AX phosphorylation (γ-H2AX) were determined by immunohistochemistry and ataxia telangiectasia mutated(ATM) protein levels were measured by western blot analysis. In addition, it would sacrifice each of group of three mice through 10 days' treatment, what's more, it would harvest tumor by virtue of flow cytometry and immunohistochemical analysis. It would like to use there maining mice to analyze tumor growth and survival. The remaining mice were analyzed for tumor growth and survival.

Indexed as

cervical cancercisplatinmicellespaclitaxelthermosensitive hydrogel

Identifiers

PMID29416613
PMCPMC5787464
OpenAlexW2772117833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.