ReviewWorld journal of emergency surgery : WJES2018
Raising concerns about the Sepsis-3 definitions.
Abstract readReview
In one paragraph
Review in World journal of emergency surgery : WJES, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 6 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Guidelines for Enhanced Recovery After Trauma and Intensive Care (ERATIC): Enhanced Recovery After Surgery (ERAS) and International Association for Trauma Surgery and Intensive Care (IATSIC) Society Recommendations: Paper 2: Postoperative and Intensive Care Recommendations.World journal of surgery · 2025Guideline
- The Diagnostic Utility of Host RNA Biosignatures in Adult Patients With Sepsis: A Systematic Review and Meta-Analysis.Critical care explorations · 2025Pooled it
- Acute cholecystitis management in high-risk, critically ill, and unfit-for-surgery patients: the Italian Society of Emergency Surgery and Trauma (SICUT) guidelines.Updates in surgery · 2024Guideline
- Sepsis Alerts in Emergency Departments: A Systematic Review of Accuracy and Quality Measure Impact.The western journal of emergency medicine · 2020Pooled it
- Perforated and bleeding peptic ulcer: WSES guidelines.World journal of emergency surgery : WJES · 2020Guideline
- Frequency and mortality of septic shock in Europe and North America: a systematic review and meta-analysis.Critical care (London, England) · 2019Pooled it
- The clinical effectiveness of sivelestat in treating sepsis patients with both acute respiratory distress syndrome and septic cardiomyopathy.Journal of cardiothoracic surgery · 2024Trial
- Improving sepsis best practice utility and clinical acceptance using an LLM-enhanced prediction system.npj health systems · 2026Article
- Sepsis Recognition and Management Gaps in Hospitals: A Post Hoc Analysis of a Subset of Data from the European Sepsis Care Survey.Infectious diseases and therapy · 2026Article
- Article
- A novel scoring system for evaluating mortality risk of patients with sepsis during early hospitalization.BMC infectious diseases · 2025Article
- Development and Validation of a Machine Learning Model for Early Prediction of Sepsis Onset in Hospital Inpatients from All Departments.Diagnostics (Basel, Switzerland) · 2025Article
- Evaluation of the Diagnostic Accuracy of Exhaled Nitric Oxide as a Marker of Infection and Sepsis in Emergency Department Patients.Emergency medicine international · 2025Article
- Advancements, Challenges, and Future Prospects of Nanotechnology in Sepsis Therapy.International journal of nanomedicine · 2025Review
- Reassessing sepsis research: new clues for old players and new players for an old symptom to improve patient outcomes.EXCLI journal · 2025Review
- Patterns, Outcomes and Economic Burden of Primary vs. Secondary Bloodstream Infections: A Single Center, Cross-Sectional Study.Pathogens (Basel, Switzerland) · 2024Article
- Hospital Acquired Sepsis, Disease Prevalence, and Recent Advances in Sepsis Mitigation.Pathogens (Basel, Switzerland) · 2024Review
- Validation of SeptiCyte RAPID to Discriminate Sepsis from Non-Infectious Systemic Inflammation.Journal of clinical medicine · 2024Article
- Sepsis-2.5: Resolving Conflicts Between Payers and Providers.Critical care explorations · 2023Article
- Source control in emergency general surgery: WSES, GAIS, SIS-E, SIS-A guidelines.World journal of emergency surgery : WJES · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
76 authors.
Massimo SartelliDepartment of Surgery, Macerata Hospital, Macerata, Italy.
Yoram Kluger2Department of General Surgery, Division of Surgery, Rambam Health Care Campus, Haifa, Israel.
Luca Ansaloni3General Surgery Department, Bufalini Hospital, Cesena, Italy.
Timothy C HardcastleTrauma Service, Inkosi Albert Luthuli Central Hospital, Durban, South Africa.
Jordi Rello5Department of Clinical Research & Innovation in Pneumonia and Sepsis, Vall d'Hebron Institute of Research (VHIR), Barcelona, Spain.
Richard R Watkins6Division of Infectious Diseases, Cleveland Clinic Akron General, Akron, OH USA.
Matteo Bassetti8Infectious Diseases Division, Santa Maria Misericordia University Hospital, Udine, Italy.
Eleni Giamarellou96th Department of Internal Medicine, Hygeia General Hospital, Athens, Greece.
Federico Coccolini3General Surgery Department, Bufalini Hospital, Cesena, Italy.
Fikri M Abu-Zidan10Department of Surgery, College of Medicine and Health Sciences, UAE University, Al-Ain, United Arab Emirates.
Abdulrashid K Adesunkanmi11Department of Surgery, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.
Goran Augustin12Department of Surgery, University Hospital Centre, Zagreb, Croatia.
Gian L Baiocchi13Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Miklosh Bala14Trauma and Acute Care Surgery Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Oussema BaraketDepartment of Surgery, Bizerte Hospital, Bizerte, Tunisia.
Marcelo A BeltranDepartment of General Surgery, Hospital San Juan de Dios de La Serena, La Serena, Chile.
Asri Che JusohDepartment of General Surgery, Kuala Krai Hospital, Kelantan, Malaysia.
Zaza DemetrashviliDepartment General Surgery, Kipshidze Central University Hospital, Tbilisi, Georgia.
Belinda De Simone19Department of Digestive Surgery, Cannes Hospital, Cannes, France.
Hamilton P de Souza20Department of Surgery, School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
Yunfeng Cui21Department of Surgery, Tianjin Nankai Hospital, Nankai Clinical School of Medicine, Tianjin Medical University, Tianjin, China.
R Justin Davies22Colorectal Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Sameer Dhingra23School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Eric Williams Medical Sciences Complex, Uriah Butler Highway, Champ Fleurs, Trinidad and Tobago.
Jose J Diaz24Division of Acute Care Surgery, Program in Trauma, R Adams Cowley Shock Trauma Center, University of Maryland, Baltimore, MD USA.
Salomone Di Saverio22Colorectal Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Agron DogjaniDepartment of Surgery, University Hospital of Trauma, Tirana, Albania.
Mutasim M Elmangory26Sudan National Public Health Laboratory, Federal Ministry of Health, Khartoum, Sudan.
Mushira A Enani27Department of Medicine, Infectious Disease Division, King Fahad Medical City, Riyadh, Saudi Arabia.
Paula Ferrada28Department of Surgery, Virginia Commonwealth University, Richmond, VA USA.
Gustavo P Fraga29Division of Trauma Surgery, Department of Surgery, School of Medical Sciences, University of Campinas (Unicamp), Campinas, SP Brazil.
Sabrina FrattimaIstituto Clinico San Rocco di Franciacorta, Brescia, Italy.
Wagih Ghnnam31Department of General Surgery, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Carlos A GomesDepartment of Surgery, Hospital Universitário Terezinha de Jesus, Faculdade de Ciências Médicas e da Saúde de Juiz de Fora, Juiz de Fora, Brazil.
Souha S Kanj33Division of Infectious Diseases, Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
Aleksandar Karamarkovic34Clinic for Emergency Surgery, Medical Faculty, University of Belgrade, Belgrade, Serbia.
Jakub Kenig35Third Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland.
Faryal Khamis36Department of Internal Medicine, Royal Hospital, Muscat, Oman.
Vladimir KhokhaDepartment of Emergency Surgery, City Hospital, Mozyr, Belarus.
Kaoru Koike38Department of Primary Care and Emergency Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kenneth Y Y KokDepartment of Surgery, The Brunei Cancer Centre, Jerudong Park, Jerudong, Brunei.
Arda Isik40Department of General Surgery, Faculty of Medicine, Erzincan University, Erzincan, Turkey.
Francesco M LabricciosaGlobal Alliance for Infections in Surgery, Porto, Portugal.
Rifat Latifi42Department of Surgery, Division of Trauma, University of Arizona, Tucson, AZ USA.
Jae G Lee43Department of Surgery, College of Medicine, Yonsei University, Seoul, South Korea.
Andrey Litvin44Surgical Disciplines, Immanuel Kant Baltic Federal University/Regional Clinical Hospital, Kaliningrad, Russian Federation.
Gustavo M Machain45Department of Surgery, Universidad Nacional de Asuncion, Asuncion, Paraguay.
Ramiro Manzano-Nunez46Clinical Research Center, Fundacion Valle del Lili, Cali, Colombia.
Piotr Major472nd Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland.
Sanjay Marwah48Department of Surgery, Post-Graduate Institute of Medical Sciences, Rohtak, India.
Michael McFarlane49Department of Surgery, Radiology, University Hospital of the West Indies, Kingston, Jamaica.
Ziad A Memish50Infectious Diseases Division, Department of Medicine, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia.
Cristian MesinaSecond Surgical Clinic, Emergency Hospital of Craiova, Craiova, Romania.
Ernest E Moore52Department of Surgery, Denver Health Medical Center, University of Colorado, Denver, CO USA.
Frederick A Moore53Department of Surgery, Division of Acute Care Surgery, and Center for Sepsis and Critical Illness Research, College of Medicine, University of Florida, Gainesville, FL USA.
Noel Naidoo54Department of Surgery, University of KwaZulu-Natal, Durban, South Africa.
Ionut NegoiDepartment of Surgery, Emergency Hospital of Bucharest, Bucharest, Romania.
Richard Ofori-AsensoResearch Unit, Health Policy Consult, Weija, Accra, Ghana.
Iyiade Olaoye57Department of Surgery, University of Ilorin, Teaching Hospital, Ilorin, Nigeria.
Carlos A Ordoñez58Department of Surgery and Critical Care, Universidad del Valle, Fundación Valle del Lili, Cali, Colombia.
Mouaqit OuadiiDepartment of Surgery, Hassan II University Hospital, Medical School of Fez, Sidi Mohamed Benabdellah University, Fez, Morocco.
Ciro Paolillo60Department of Emergency Medicine, Santa Maria Misericordia University Hospital, Udine, Italy.
Edoardo Picetti61Department of Anesthesia and Intensive Care, Azienda Ospedaliero-Universitaria Parma, Parma, Italy.
Tadeja Pintar62Department of Surgery, UMC Ljubljana, Ljubljana, Slovenia.
Alfredo Ponce-de-Leon63Laboratory of Clinical Microbiology, Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Guntars Pupelis64Department of General and Emergency Surgery, Riga East University Hospital "Gailezers", Riga, Latvia.
Tarcisio ReisEmergency Post-Operative Department, Otavio De Freitas Hospital, Recife, Brazil.
Boris SakakushevGeneral Surgery Department, Medical University, University Hospital St George, Plovdiv, Bulgaria.
Hossein Samadi Kafil67Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Norio Sato68Department of Aeromedical Services for Emergency and Trauma Care, Graduate School of Medicine, Ehime University, Ehime, Japan.
Jay N Shah69Department of Surgery, Patan Hospital, Patan Academy of Health Sciences Lalitpur, Kathmandu, Nepal.
Boonying Siribumrungwong70Department of Surgery, Faculty of Medicine, Thammasat University Hospital, Thammasat University, Rangsit, Pathum Thani Thailand.
Peep TalvingDepartment of Surgery, North Estonia Medical Center, Tallinn, Estonia.
Cristian TranàDepartment of Surgery, Macerata Hospital, Macerata, Italy.
Jan Ulrych72First Department of Surgery, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
Kuo-Ching Yuan73Department of Emergency and Critical Care Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
Fausto CatenaDepartment of Emergency Surgery, Parma Maggiore Hospital, Parma, Italy.
Funding
PICS: A New Horizon for Surgical Critical CareP50GM111152 · NIGMS · UNIVERSITY OF FLORIDA · PI MOORE, FREDERICK A · 2014 to 2018
$10.7MNIGMS NIH HHS P50 GM111152
Abstract
The Global Alliance for Infections in Surgery appreciates the great effort of the task force who derived and validated the Sepsis-3 definitions and considers the new definitions an important step forward in the evolution of our understanding of sepsis. Nevertheless, more than a year after their publication, we have a few concerns regarding the use of the Sepsis-3 definitions.
Indexed as
Data AccuracySeverity of Illness IndexArterial PressureConsensusGlasgow Coma ScaleHumansOrgan Dysfunction ScoresSensitivity and SpecificitySepsisInfectionsOrgan dysfunctionSepsisSeptic shock
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.