ReviewImmunity & ageing : I & A2018
Interventions to restore appropriate immune function in the elderly.
Review in Immunity & ageing : I & A, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- The global scenario of lumpy skin disease, its epidemiological investigation, and prevalence in livestock: A review.Veterinary and animal science · 2026Review
- The role of biological age in stroke prediction: evidence from CHARLS and machine learning models.BMC neurology · 2026Article
- Treatment outcome and safety of durvalumab after concurrent chemoradiation in very elderly patients with unresectable stage III non-small cell lung cancer.Translational lung cancer research · 2025Article
- Targeting immunosenescence and inflammaging: advancing longevity research.Experimental & molecular medicine · 2025Review
- Treatment outcomes and safety of concurrent chemoradiation in older adults with unresectable stage III non-small-cell lung cancer.Journal of thoracic disease · 2025Article
- Microbial contamination of therapeutic contact lenses after photorefractive keratectomy: a prospective analysis.Journal of ophthalmic inflammation and infection · 2025Article
- Review
- Inflammaging, immunosenescence, and cardiovascular aging: insights into long COVID implications.Frontiers in cardiovascular medicine · 2024Review
- The immunobiology of SARS-CoV-2 infection and vaccine responses: potential influences of cross-reactive memory responses and aging on efficacy and off-target effects.Frontiers in immunology · 2024Review
- Usability of a new digital walking program for older adults: a pilot study.BMC geriatrics · 2023Article
- Article
- SARS-CoV-2, COVID-19 and the Ageing Immune System.Nature aging · 2021Article
- Patient-Reported Complications after Intravitreal Injection and Their Predictive Factors.Ophthalmology. Retina · 2021Article
- Effects of zinc status on age-related T cell dysfunction and chronic inflammation.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Article
- The conundrum of human immune system "senescence".Mechanisms of ageing and development · 2020Review
- Cardiovascular involvement during COVID-19 and clinical implications in elderly patients. A review.Annals of medicine and surgery (2012) · 2020Review
- Review
- Physical Exercise Potentials Against Viral Diseases Like COVID-19 in the Elderly.Frontiers in medicine · 2020Article
- Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging.Immunity & ageing : I & A · 2020Review
- Gliotoxin Aggravates Experimental Autoimmune Encephalomyelitis by Triggering Neuroinflammation.Toxins · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advanced age is one indicator of likely immune dysfunction. As worldwide, the global population contains progressively more and more older individuals there is likelihood of an increased prevalence and incidence of infectious diseases due to common and emergent pathogens. The resultant increase in mortality and morbidity would be matched by the risk of functional decline and disability. Maintaining immune function at a plateau throughout life may therefore be associated with considerable cost savings. The aim of improving immune function in older individuals may be achieved through considering a therapeutic approach to rejuvenate, stimulate or support the indigenous immune system to perform in a more optimal manner. In terms of cost effectiveness a therapeutic approach may prove difficult because of issues associated with; identifying those who would benefit the most from this treatment, identifying the type of treatment which would suit them and identifying whether the treatment was successful. The alternative of supporting or providing a stronger stimulus through vaccination, whilst more cost effective, may be a more valuable option in the short term. Both approaches will be addressed in this review.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.