ArticleUrology annals
Metabolic evaluation of children with urolithiasis.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relationship Between theFrontiers in genetics · 2020Pooled it
- Efficacy and Safety of Percutaneous Nephrolithotomy in Children: A Single-Center Retrospective Analysis.Cureus · 2026Article
- Metabolic and genetic spectrum of pediatric nephrolithiasis: insights from high-prevalence desert belt in India.Urolithiasis · 2026Observational
- The impact of urine pH on lithogenic risk profile in children with urolithiasis.Pediatric nephrology (Berlin, Germany) · 2026Article
- CaSR regulates SLC26A6 expression via the PKA-FOXO4 signaling axis to promote experimental calcium oxalate kidney stone formation in rats.Frontiers in cell and developmental biology · 2026Article
- 2,8-Dihydroxyadenine nephrolithiasis with chronic kidney disease in children: A case report and review of literature.Urology case reports · 2023Article
- Serum and 24-hour urinary tests cost-effectiveness in stone formers.BMC urology · 2023Article
- Upper urolithiasis in cats with chronic kidney disease: prevalence and investigation of serum and urinary calcium concentrations.Journal of feline medicine and surgery · 2022Article
- Minimally invasive surgery for pediatric renal and ureteric stones: A therapeutic update.Frontiers in pediatrics · 2022Review
- Clinical Features and Surgical Outcomes of the Children With Urolithiasis at a Tertiary Care Hospital: First Report From Somalia.Frontiers in pediatrics · 2022Article
- Calcium oxalate urolithiasis in juvenile dogs.The Veterinary record · 2021Article
- Minimally Invasive Treatment of Urolithiasis in Children: Evaluation of the Use of Flexible Ureterorenoscopy and Laser Lithotripsy.Translational medicine @ UniSa · 2020Article
- The current status of preventive measures for urinary calculi in children.Therapeutic advances in urologyReview
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe aim of the study is to identify the prevalence of metabolic abnormalities in children with urolithiasis. MATERIALS AND
methodsThis is a prospective study; all children below 15 years who are found to have urolithiasis were prospectively evaluated with relevant history, clinical examination, and urine and serum testing. Metabolic workup includes complete urine examination, urine culture and sensitivity, and 24-h urinary analysis (lithorisk profile).
resultsA total of 55 patients are included in the study. Forty-two are boys and 13 are girls aged between from 8 months to 15 years. Thirty-three patients underwent stone analysis, primary composition of calcium oxalate stones in 19 (58%), ammonium urate in 4, dahlite in 3 and uric acid in 3, silicon oxide in 2, and struvite in 2 cases. Lithorisk profile was performed in 40 cases (72.7%). The pH range is 5.6-6.2. We noted hypercalciuria in 20 patients (50%), hyperuricosuria in 23 (57.5%), hyperoxaluria in 20 (50%), hypernatriuria in 26 (65%), hypocitraturia in 9 (23%), and hypomagnesuria in 3 (7.5%). Urine calcium-to-creatinine ratio >0.2 was found in 22 (55%) patients. Statistically significant association between hyperoxaluria and hyperuricosuria (
conclusionBecause of high prevalence of metabolic risk factors and the significant risk of lifelong recurrence, all children with urolithiasis need complete evaluation with metabolic workup.
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