ArticleJournal of anaesthesiology, clinical pharmacology
Effect of lactate versus acetate-based intravenous fluids on acid-base balance in patients undergoing free flap reconstructive surgeries.
Article in Journal of anaesthesiology, clinical pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- EngineeredACS synthetic biology · 2025Article
- ERAS-Based Anesthetic Management of Patients Undergoing Abdominal-Based Free Flap Breast Reconstruction: A Narrative Review.JPRAS open · 2024Review
- EngineeredbioRxiv : the preprint server for biology · 2024Article
- Highly Adhesive Antimicrobial Coatings for External Fixation Devices.Gels (Basel, Switzerland) · 2023Article
- The efficacy of sodium bicarbonated Ringer's solution versus lactated Ringer's solution in elderly patients undergoing gastrointestinal surgery: a prospective randomized controlled trial.American journal of translational research · 2023Article
- Increased crystalloid fluid requirements during zone 3 Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) versus Abdominal Aortic and Junctional Tourniquet (AAJT) after class II hemorrhage in swine.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Influence of acetate- vs. lactate-containing fluid bolus therapy on acid-base status, electrolytes, and plasma lactate in dogs.Frontiers in veterinary science · 2022Article
- The effect of acetate Ringer's solution versus lactate Ringer's solution on acid base physiology in infants with biliary atresia.BMC pediatrics · 2021Article
- Influence of acetate containing fluid versus lactate containing fluid on acid-base status, electrolyte level, and blood lactate level in dehydrated dogs.Veterinary world · 2021Article
- Comparison of Balanced Crystalloid Solutions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Critical care explorations · 2021Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsUse of lactated intravenous fluids during long surgeries could cause lactate accumulation and lactic acidosis. Acetate-based solutions could be advantageous as they are devoid of lactate. The primary aim of the study was to assess the effect of use of an acetated solution or Ringer's lactate (RL) as intraoperative fluid on lactate levels in patients without hepatic dysfunction undergoing prolonged surgeries. MATERIAL AND
methodsThis was a prospective, randomized, controlled trial involving sixty patients belonging to American Society of Anesthesiologists Physical Status I to II undergoing major head and neck surgeries with free flap reconstruction. Patients were randomly allocated into two equal groups, Group sterofundin (SF) and Group RL. Group SF was started on acetate-based crystalloid solution (sterofundin B Braun
resultsIntraoperative lactate levels were significantly high in RL group at 2, 4, 6, and 8 h. The pH was comparable between groups except at 8 h where RL group had a significantly lower pH than SF group (7.42 ± 0.1 vs. 7.4 ± 0.1). Sodium, potassium, chloride, bicarbonate, and pCO
conclusionUse of acetate-based intravenous solutions reduced levels of lactate in comparison with RL in patients undergoing free flap reconstructive surgeries.
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