Evidence map›Paper›PMID 29416226›Full record

ArticleActa veterinaria2017

A BRIEF REVIEW ON THE MODE OF ACTION OF ANTINEMATODAL DRUGS.

Melanie Abongwa, Richard J Martin, Alan P Robertson

Abstract read
In one paragraph

Article in Acta veterinaria, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

  1. Exploratory Evaluation ofVeterinary sciences · 2026
    Article
  2. Article
  3. Non-Invasive Diagnosis and Management of PancreaticAnimals : an open access journal from MDPI · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Preclinical Evaluation of Fenbendazole for ControllingAnimals : an open access journal from MDPI · 2025
    Article
  12. Dietary Fenbendazole Treatment Does Not Impair Skilled Forelimb Motor Function in C57BL/6J Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Article
  13. Occurrence of Internal Parasites and Anthelmintic Resistance in Goats.Animals : an open access journal from MDPI · 2025
    Article
  14. Article
  15. Response of Northern bobwhite (International journal for parasitology. Parasites and wildlife · 2024
    Review
  16. Article
  17. Article
  18. In Vitro Lethality of Fenbendazole to the EyewormAnimals : an open access journal from MDPI · 2024
    Article
  19. Article
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Melanie AbongwaDepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.
Richard J MartinDepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.
Alan P RobertsonDepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.

Funding

RESISTANCE &MODULATION OF LEVAMISOLE RECEPTOR CHANNELSR01AI047194 · NIAID · IOWA STATE UNIVERSITY · PI MARTIN, RICHARD JOHN · 2001 to 2021
$5.8M
Eating worms: an unusual nicotinic acetylcholine receptor from the nematode pharynx as a potential drug targetR21AI121831 · NIAID · IOWA STATE UNIVERSITY · PI ROBERTSON, ALAN P · 2016 to 2017
$393k
NIAID NIH HHS R01 AI047194NIAID NIH HHS R21 AI121831
6 · The paper itself

Abstract

Anthelmintics are some of the most widely used drugs in veterinary medicine. Here we review the mechanism of action of these compounds on nematode parasites. Included are the older classes of compounds; the benzimidazoles, cholinergic agonists and macrocyclic lactones. We also consider newer anthelmintics, including emodepside, derquantel and tribendimidine. In the absence of vaccines for most parasite species, control of nematode parasites will continue to rely on anthelmintic drugs. As a consequence, vigilance in detecting drug resistance in parasite populations is required. Since resistance development appears almost inevitable, there is a continued and pressing need to fully understand the mode of action of these compounds. It is also necessary to identify new drug targets and drugs for the continued effective control of nematode parasites.

Indexed as

anthelminticavermectinsbenzimidazolescholinergicderquantelemodepsideparasite

Identifiers

PMID29416226
PMCPMC5798647

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.