Evidence map›Paper›PMID 29416098›Full record

ArticleScientific reports2018

Breastfeeding moderates FTO related adiposity: a birth cohort study with 30 years of follow-up.

Bernardo Lessa Horta, Cesar G Victora, Giovanny V A França, Fernando P Hartwig, Ken K Ong, Emanuella de Lucia Rolfe, Elma I S Magalhães, Natalia P Lima, Fernando C Barros

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Exclusive Breastfeeding and Growth Trajectories Until 5 Years of Age Among Children Monitored in Primary Health Care in Brazil.American journal of human biology : the official journal of the Human Biology Council · 2026
    Article
  5. Review
  6. Article
  7. The interaction of breastfeeding and genetic factors on childhood obesity.European journal of obstetrics & gynecology and reproductive biology: X · 2024
    Review
  8. Article
  9. Breastfeeding moderates the relationship betweenObesity science & practice · 2022
    Article
  10. lncRNAInternational journal of molecular medicine · 2021
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Bernardo Lessa HortaPostgradute Programme in Epidemiology, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil. blhorta@gmail.com.ORCID 0000-0001-9843-412X
Cesar G VictoraPostgradute Programme in Epidemiology, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Giovanny V A FrançaSecretariat of Health Surveillance, Ministry of Health, Brasilia, Brazil.
Fernando P HartwigPostgradute Programme in Epidemiology, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID 0000-0003-3729-0710
Ken K OngMedical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, England.
Emanuella de Lucia RolfeMedical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, England.
Elma I S MagalhãesPostgradute Programme in Epidemiology, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Natalia P LimaPostgradute Programme in Epidemiology, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Fernando C BarrosUniversidade Católica de Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Universidade Federal de Pelotas · BRUniversity of Cambridge · GBMinistério da Saúde · BRUniversidade Católica de Pelotas · BR

Funding

Medical Research Council MC_UU_12015/2
6 · The paper itself

Abstract

This study assessed the association of breastfeeding with body composition at 30 years, among subjects who have been prospectively followed since birth in a southern Brazilian city. We also evaluated whether breastfeeding moderated the association between the rs9939609 variant in the FTO gene and adiposity. At 30 years, total and predominant breastfeeding were positively associated with lean mass index and inversely with visceral fat thickness. Among subjects breastfed for <1 month, all outcomes showed monotonically increasing values with additional copies of the A allele in the FTO genotype (rs9939609). Associations among subjects breastfed for one month or longer tended to be in the same direction but showed lower magnitude and were less consistent; for all outcomes. Interactions had p values ≤ 0.05 for body mass index, fat mass index and waist circumference. Even among young adults, breastfeeding moderates the association between the FTO variant rs9939609 and body composition.

Indexed as

Breast FeedingAdiposityAdultAlpha-Ketoglutarate-Dependent Dioxygenase FTOBody CompositionBody Mass IndexBrazilCohort StudiesFemaleFollow-Up StudiesGenetic Predisposition to DiseaseHumansMaleObesityPolymorphism, Single NucleotideAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, human

Identifiers

PMID29416098
PMCPMC5803210
OpenAlexW2799953615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.