Evidence map›Paper›PMID 29416082›Full record

ArticleScientific reports2018

Pyrazines from bacteria and ants: convergent chemistry within an ecological niche.

Eduardo A Silva-Junior, Antonio C Ruzzini, Camila R Paludo, Fabio S Nascimento, Cameron R Currie, Jon Clardy, Mônica T Pupo

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 68 citations in OpenAlex.

  1. Ecology and evolution of pyrazines in insects.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Pyrazines Biosynthesis byBiomolecules · 2021
    Article
  12. Article
  13. Review
  14. Ammonia Production byMicroorganisms · 2021
    Article
  15. Article
  16. An evolutionary conserved olfactory receptor for foodborne and semiochemical alkylpyrazines.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Eduardo A Silva-JuniorFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, 14040903, Brazil.
Antonio C RuzziniDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, United States of America.
Camila R PaludoFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, 14040903, Brazil.
Fabio S NascimentoDepartamento de Biologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, 14040901, Brazil.
Cameron R CurrieDepartment of Bacteriology, University of Wisconsin, Madison, WI, 53706, United States of America.
Jon ClardyDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, United States of America.ORCID 0000-0003-0213-8356
Mônica T PupoFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, 14040903, Brazil. mtpupo@fcfrp.usp.br.ORCID 0000-0003-2705-0123
Harvard University · USUniversidade de Ribeirão Preto · BRUniversidade de São Paulo · BRUniversity of Wisconsin–Madison · US

Funding

Novel therapeutic agents from the bacterial symbionts of Brazilian invertebratesU19TW009872 · FIC · HARVARD MEDICAL SCHOOL · PI CLARDY, JON, PUPO, MONICA T · 2014 to 2018
$4.4M
CIHRFIC NIH HHS U19 TW009872
6 · The paper itself

Abstract

Ants use pheromones to coordinate their communal activity. Volatile pyrazines, for instance, mediate food resource gathering and alarm behaviors in different ant species. Here we report that leaf-cutter ant-associated bacteria produce a family of pyrazines that includes members previously identified as ant trail and alarm pheromones. We found that L-threonine induces the bacterial production of the trail pheromone pyrazines, which are common for the host leaf-cutter ants. Isotope feeding experiments revealed that L-threonine along with sodium acetate were the biosynthetic precursors of these natural products and a biosynthetic pathway was proposed.

Indexed as

AnimalsAntsEcosystemGas Chromatography-Mass SpectrometryPheromonesPyrazinesSerratia marcescensSodium AcetateThreoninePheromonesPyrazinesSodium AcetateThreonine

Identifiers

PMID29416082
PMCPMC5803209
OpenAlexW2789645382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.