ArticleScientific reports2018
Adverse drug events in Chinese pediatric inpatients and associated risk factors: a retrospective review using the Global Trigger Tool.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Machine learning to predict adverse drug events based on electronic health records: a systematic review and meta-analysis.The Journal of international medical research · 2024Pooled it
- Predicting adverse drug event using machine learning based on electronic health records: a systematic review and meta-analysis.Frontiers in pharmacology · 2024Pooled it
- Genetic PolymorphismsPharmaceuticals (Basel, Switzerland) · 2026Article
- Development and evaluation of a German Paediatric Trigger Tool (PAED-TT-GER) for detecting adverse events in hospitalized children.European journal of pediatrics · 2026Article
- Sequential analysis for post-marketing drug safety surveillance using routinely collected electronic healthcare data: a scoping review.Therapeutic advances in drug safety · 2026Article
- Active surveillance of adverse drug events in hospitalized patients with pulmonary arterial hypertension based on the global trigger tool.Frontiers in pharmacology · 2025Article
- Evaluating the Economic Impact of the PedAMINES App in Reducing Medication Errors in Pediatric Emergency Care: Cost-Effectiveness Analysis.Journal of medical Internet research · 2024Article
- Implementation of the pharmacovigilance database in the usage of antibiotics in a tertiary care hospital: A pilot study.Health science reports · 2024Article
- Adverse Drug Reactions Related with Antibiotic Medicines in Malawi: A Retrospective Analysis of Prevalence and Associated Factors.Drug, healthcare and patient safety · 2024Article
- Risk Factors Associated With Drug-Related Side Effects in Children: A Scoping Review.Global pediatric health · 2024Article
- Adverse drug events and contributing factors among pediatric cancer patients at Jimma University medical center, Southwest Ethiopia.BMC pediatrics · 2023Observational
- Adverse drug events in Chinese elder inpatients: a retrospective review for evaluating the efficiency of the Global Trigger Tool.Frontiers in medicine · 2023Article
- Predicting Adverse Drug Events in Chinese Pediatric Inpatients With the Associated Risk Factors: A Machine Learning Study.Frontiers in pharmacology · 2021Article
- Assessing the development and implementation of the Global Trigger Tool method across a large health system in Sicily.F1000Research · 2019Article
- Causality and preventability assessment of adverse drug events of antibiotics among inpatients having different lengths of hospital stay: a multicenter, cross-sectional study in Lahore, Pakistan.BMC pharmacology & toxicology · 2018Observational
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Understanding the epidemiology and risk factors of adverse drug events (ADEs) in pediatric inpatient is essential if we are to prevent, reduce or ameliorate the harm experienced. The Global Trigger Tool (GTT) is a method of retrospective medical record review that measures harm in hospitalized children. We employed a three-stage retrospective chart review of random samples of 1800 pediatric inpatients discharged from January 2013 to December 2015. 31 kinds of pediatric-specific triggers were made based on the previous trigger tool studies developed for use in adult or pediatric. Positive predictive value (PPV) of individual triggers, as well as ADEs detection rates were calculated. Stepwise logistic regression was performed to investigate risk factors associated with ADEs. Of 1746 patients, detected in 221 patients (12.7%) with 247 ADEs. The PPV of the trigger tool was 13.3%. Of the 247 ADEs, 82.6% were identified as category E, 11.7% category F and 5.7% category H. The pediatric-focused trigger tool is a feasible and useful tool for detecting pediatric ADEs. Especially for patients who have had more drugs, more doses or more admissions which needs to be closely monitored as triggers to improve the safety.
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