Evidence map›Paper›PMID 29416015›Full record

ArticleCell death & disease2018

Multiple molecular mechanisms form a positive feedback loop driving amyloid β42 peptide-induced neurotoxicity via activation of the TRPM2 channel in hippocampal neurons.

Xin Li, Lin-Hua Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 59 citations in OpenAlex.

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  16. Review
  17. TPEN attenuates amyloid-βMolecular brain · 2021
    Article
  18. Review
  19. Reactive Oxygen Species-Induced TRPM2-Mediated CaAntioxidants (Basel, Switzerland) · 2021
    Review
  20. Research progress on transient receptor potential melastatin 2 channel in nervous system diseases.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Xin LiSchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK.
Lin-Hua JiangSchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK. l.h.jiang@leeds.ac.uk.ORCID 0000-0001-6398-0411
University of Leeds · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence supports an important role for the ROS-sensitive TRPM2 channel in mediating age-related cognitive impairment in Alzheimer's disease (AD), particularly neurotoxicity resulting from generation of excessive neurotoxic Aβ peptides. Here we examined the elusive mechanisms by which Aβ

Indexed as

Amyloid beta-PeptidesAnimalsEthylaminesHEK293 CellsHippocampusHumansLysosomesMiceMice, Inbred C57BLMice, KnockoutNeuronsPeptide FragmentsPyridinesReactive Oxygen SpeciesTRPM Cation ChannelsZincAmyloid beta-Peptidesamyloid beta-protein (1-42)EthylaminesN,N,N',N'-tetrakis(2-pyridylmethyl)ethane-1,2-diaminePeptide FragmentsPyridinesReactive Oxygen SpeciesTRPM2 protein, humanTRPM2 protein, mouseTRPM Cation ChannelsZinc

Identifiers

PMID29416015
PMCPMC5833848
OpenAlexW2794125014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.