Evidence map›Paper›PMID 29415856›Full record

ArticleJournal of substance abuse treatment2018

A qualitative assessment of attitudes about and preferences for extended-release naltrexone, a new pharmacotherapy to treat opioid use disorders in Ukraine.

Ruthanne Marcus, Martha J Bojko, Alyona Mazhnaya, Iuliia Makarenko, Sergii Filippovych, Sergii Dvoriak, Frederick L Altice, Sandra A Springer

Abstract read
In one paragraph

Article in Journal of substance abuse treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Ruthanne MarcusYale School of Medicine, Section of Infectious Diseases, New Haven, CT, USA. Electronic address: Ruthanne.marcus@yale.edu.
Martha J BojkoYale School of Medicine, Section of Infectious Diseases, New Haven, CT, USA.
Alyona MazhnayaICF Alliance for Public Health, Kyiv, Ukraine.
Iuliia MakarenkoICF Alliance for Public Health, Kyiv, Ukraine.
Sergii FilippovychICF Alliance for Public Health, Kyiv, Ukraine.
Sergii DvoriakUkrainian Institute on Public Health Policy, Kyiv, Ukraine.
Frederick L AlticeYale School of Medicine, Section of Infectious Diseases, New Haven, CT, USA; Yale School of Public Health, Division of Epidemiology of Microbial Diseases, New Haven, CT, USA; Centre of Excellence on Research in AIDS (CERiA), University of Malaya, Kuala Lumpur, Malaysia.
Sandra A SpringerYale School of Medicine, Section of Infectious Diseases, New Haven, CT, USA.
Yale University · USAlliance for Public Health · UAUkrainian Institute of Public Health Policy · UA

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
Training in the Epidemiology of HPV/Cervical Neoplasia Among HIV+ WomenD43TW000233 · FIC · SUNY DOWNSTATE MEDICAL CENTER · PI DEHOVITZ, JACK A · 1993 to 2015
$10.1M
Prison Interventions and HIV Prevention CollaborationR01DA029910 · NIDA · YALE UNIVERSITY · PI FREDERICK LEWIS ALTICE · 2010 to 2026
$7.9M
Expanding Medication Assisted Therapy in Ukraine (ExMAT)R01DA033679 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2012 to 2021
$6.4M
Global Health Fellows and Scholars Research TrainingR25TW009338 · FIC · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARRY, MICHELE, KO, ALBERT ICKSANG · 2012 to 2016
$5.2M
Ukraine HIV Research Training ProgramD43TW010562 · FIC · SUNY DOWNSTATE MEDICAL CENTER · PI DEHOVITZ, JACK A · 2017 to 2021
$1.7M
Enhancing Health Outcomes Among HIV+ Substance AbusersK24DA017072 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2003 to 2012
$1.5M
Medication Assisted Therapy as a Conduit to Care for HIV+ CJS Populations TransitK02DA032322 · NIDA · YALE UNIVERSITY · PI SPRINGER, SANDRA ANN · 2011 to 2022
$1.3M
Ukraine HIV Research Training Program/Aging SupplementD43TW012491 · FIC · SUNY DOWNSTATE MEDICAL CENTER · PI Jack A DeHovitz, Tetiana Kiriazova · 2023 to 2026
$1.0M
FIC NIH HHS D43 TW000233FIC NIH HHS D43 TW010540FIC NIH HHS D43 TW010562FIC NIH HHS D43 TW012491FIC NIH HHS R25 TW009338NCATS NIH HHS UL1 TR001863NIDA NIH HHS K02 DA032322NIDA NIH HHS K24 DA017072NIDA NIH HHS R01 DA029910NIDA NIH HHS R01 DA033679
6 · The paper itself

Abstract

Numerous individual barriers, including negative attitudes toward opioid agonist therapies (OAT), have undermined HIV prevention efforts in Ukraine where the epidemic is concentrated in people who inject drugs (PWID). The recent availability of extended-release naltrexone (XR-NTX), an opioid antagonist, provides new opportunities for treatment and prevention, but little is known about patient preferences. We conducted qualitative analysis using focus groups (FG) of PWID recruited based on OAT experience: currently, previously, and never on OAT in five Ukrainian cities. FG included 199 PWID in 25 focus groups. Focus group transcripts were coded and analyzed using a modified grounded theory approach to identify common themes and domains related to attitudes about and preferences for XR-NTX, relative to other treatments. Interest in XR-NTX was supported if supervised opioid withdrawal and psychological support were assured. Other factors supporting XR-NTX included a focus on younger PWID early in their injection career and motivated for recovery. Perceptions of recovery included not receiving psychoactive medications like methadone or buprenorphine. With more information, XR-NTX could be a viable option for PWID in Ukraine, especially if concerns regarding withdrawal and psychological support are adequately addressed.

Indexed as

Patient PreferenceAdultDelayed-Action PreparationsFemaleFocus GroupsHumansMaleNaltrexoneNarcotic AntagonistsOpioid-Related DisordersUkraineDelayed-Action PreparationsNaltrexoneNarcotic AntagonistsAddictionExtended-release naltrexone (Vivitrol®)HIVImplementation scienceMedication-assisted treatmentOpioid use disordersPatient preferencesPeople who inject drugsUkraine

Identifiers

PMID29415856
PMCPMC5808584
OpenAlexW2782143967

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.